Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Pisl_2015TIGRFAM: peptidase S26B, signal peptidase; PFAM: peptidase S24, S26A and S26B; KEGG: pai:PAE0264 signal peptidase. (197 aa)    
Predicted Functional Partners:
Pisl_2014
KEGG: pai:PAE0269 ABC-2 type transport system ATP-binding protein; TIGRFAM: daunorubicin resistance ABC transporter ATPase subunit; PFAM: ABC transporter related; SMART: AAA ATPase.
     
 0.761
rnhB
RNase HII; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family.
  
  
 0.756
Pisl_2013
PFAM: ABC-2 type transporter; KEGG: pai:PAE0270 membrane protein.
       0.730
Pisl_1052
PFAM: H+-transporting two-sector ATPase, C subunit; KEGG: pai:PAE0754 H+-transporting ATP synthase subunit C.
    
 0.645
Pisl_1053
KEGG: pai:PAE0753 H+-transporting ATP synthase subunit C.
    
 0.640
lig
DNA ligase I, ATP-dependent Dnl1; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.
   
 0.634
atpE
H+-transporting two-sector ATPase, E subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane.
    
 0.632
atpB
Sodium-transporting two-sector ATPase; Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit.
    
 0.631
Pisl_1615
TIGRFAM: twin-arginine translocation protein, TatA/E family subunit; PFAM: sec-independent translocation protein mttA/Hcf106; KEGG: pai:PAE1546 putative sec-independent protein translocase protein.
 
  
 0.621
Pisl_1310
PFAM: peptidase S9, prolyl oligopeptidase active site domain protein; KEGG: pai:PAE1189 acylamino-acid-releasing enzyme, conjectural.
  
 
 0.616
Your Current Organism:
Pyrobaculum islandicum
NCBI taxonomy Id: 384616
Other names: P. islandicum DSM 4184, Pyrobaculum islandicum DSM 4184, Pyrobaculum islandicum str. DSM 4184, Pyrobaculum islandicum strain DSM 4184
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