node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
PSEEN0434 | iscR | PSEEN0434 | PSEEN1009 | Putative DnaJ-like co-chaperone; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; molecular chaperone. | Iron-sulfur cluster assembly transcription factor IscR; Regulates the transcription of several operons and genes involved in the biogenesis of Fe-S clusters and Fe-S-containing proteins. | 0.419 |
PSEEN0434 | iscS-1 | PSEEN0434 | PSEEN1010 | Putative DnaJ-like co-chaperone; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; molecular chaperone. | Cysteine desulfurase; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily. | 0.549 |
PSEEN0434 | iscS-2 | PSEEN0434 | PSEEN3349 | Putative DnaJ-like co-chaperone; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; molecular chaperone. | Cysteine desulfurase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.549 |
PSEEN0434 | iscU | PSEEN0434 | PSEEN1011 | Putative DnaJ-like co-chaperone; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; molecular chaperone. | Iron-sulfur cluster assembly protein IscU; A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters. | 0.915 |
PSEEN0434 | nfuA | PSEEN0434 | PSEEN3379 | Putative DnaJ-like co-chaperone; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; molecular chaperone. | Conserved hypothetical protein; Involved in iron-sulfur cluster biogenesis. Binds a 4Fe-4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe/S proteins. Could also act as a scaffold/chaperone for damaged Fe/S proteins. | 0.857 |
PSEEN1203 | iscU | PSEEN1203 | PSEEN1011 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function; Belongs to the glutaredoxin family. Monothiol subfamily. | Iron-sulfur cluster assembly protein IscU; A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters. | 0.441 |
PSEEN1203 | nfuA | PSEEN1203 | PSEEN3379 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function; Belongs to the glutaredoxin family. Monothiol subfamily. | Conserved hypothetical protein; Involved in iron-sulfur cluster biogenesis. Binds a 4Fe-4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe/S proteins. Could also act as a scaffold/chaperone for damaged Fe/S proteins. | 0.771 |
PSEEN1203 | sdhB | PSEEN1203 | PSEEN3641 | Conserved hypothetical protein; Homologs of previously reported genes of unknown function; Belongs to the glutaredoxin family. Monothiol subfamily. | Succinate dehydrogenase, iron-sulfur subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.422 |
fdx1 | nfuA | PSEEN0289 | PSEEN3379 | Ferredoxin 4Fe-4S; Function of homologous gene experimentally demonstrated in an other organism; carrier. | Conserved hypothetical protein; Involved in iron-sulfur cluster biogenesis. Binds a 4Fe-4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe/S proteins. Could also act as a scaffold/chaperone for damaged Fe/S proteins. | 0.812 |
fdx1 | sdhB | PSEEN0289 | PSEEN3641 | Ferredoxin 4Fe-4S; Function of homologous gene experimentally demonstrated in an other organism; carrier. | Succinate dehydrogenase, iron-sulfur subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.798 |
hscB | iscR | PSEEN1013 | PSEEN1009 | Co-chaperone protein Hsc20, HscB; Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA; Belongs to the HscB family. | Iron-sulfur cluster assembly transcription factor IscR; Regulates the transcription of several operons and genes involved in the biogenesis of Fe-S clusters and Fe-S-containing proteins. | 0.927 |
hscB | iscS-1 | PSEEN1013 | PSEEN1010 | Co-chaperone protein Hsc20, HscB; Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA; Belongs to the HscB family. | Cysteine desulfurase; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily. | 0.975 |
hscB | iscS-2 | PSEEN1013 | PSEEN3349 | Co-chaperone protein Hsc20, HscB; Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA; Belongs to the HscB family. | Cysteine desulfurase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.873 |
hscB | iscU | PSEEN1013 | PSEEN1011 | Co-chaperone protein Hsc20, HscB; Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA; Belongs to the HscB family. | Iron-sulfur cluster assembly protein IscU; A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters. | 0.997 |
hscB | nfuA | PSEEN1013 | PSEEN3379 | Co-chaperone protein Hsc20, HscB; Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA; Belongs to the HscB family. | Conserved hypothetical protein; Involved in iron-sulfur cluster biogenesis. Binds a 4Fe-4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe/S proteins. Could also act as a scaffold/chaperone for damaged Fe/S proteins. | 0.857 |
iscR | PSEEN0434 | PSEEN1009 | PSEEN0434 | Iron-sulfur cluster assembly transcription factor IscR; Regulates the transcription of several operons and genes involved in the biogenesis of Fe-S clusters and Fe-S-containing proteins. | Putative DnaJ-like co-chaperone; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; molecular chaperone. | 0.419 |
iscR | hscB | PSEEN1009 | PSEEN1013 | Iron-sulfur cluster assembly transcription factor IscR; Regulates the transcription of several operons and genes involved in the biogenesis of Fe-S clusters and Fe-S-containing proteins. | Co-chaperone protein Hsc20, HscB; Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA; Belongs to the HscB family. | 0.927 |
iscR | iscS-1 | PSEEN1009 | PSEEN1010 | Iron-sulfur cluster assembly transcription factor IscR; Regulates the transcription of several operons and genes involved in the biogenesis of Fe-S clusters and Fe-S-containing proteins. | Cysteine desulfurase; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily. | 0.960 |
iscR | iscS-2 | PSEEN1009 | PSEEN3349 | Iron-sulfur cluster assembly transcription factor IscR; Regulates the transcription of several operons and genes involved in the biogenesis of Fe-S clusters and Fe-S-containing proteins. | Cysteine desulfurase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.814 |
iscR | iscU | PSEEN1009 | PSEEN1011 | Iron-sulfur cluster assembly transcription factor IscR; Regulates the transcription of several operons and genes involved in the biogenesis of Fe-S clusters and Fe-S-containing proteins. | Iron-sulfur cluster assembly protein IscU; A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters. | 0.958 |