node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
PSEEN3126 | cysG | PSEEN3126 | PSEEN2217 | Putative ferredoxin reductase component; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. | Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | 0.946 |
PSEEN3126 | hemC | PSEEN3126 | PSEEN5353 | Putative ferredoxin reductase component; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.517 |
PSEEN3126 | hemD | PSEEN3126 | PSEEN5352 | Putative ferredoxin reductase component; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. | Uroporphyrinogen III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | 0.638 |
PSEEN3126 | hemE | PSEEN3126 | PSEEN0339 | Putative ferredoxin reductase component; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.452 |
PSEEN5350 | PSEEN5351 | PSEEN5350 | PSEEN5351 | Putative hemY protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; factor. | Putative uroporphyrin-III C-methyltransferase HemX; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. | 0.979 |
PSEEN5350 | algR | PSEEN5350 | PSEEN5354 | Putative hemY protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; factor. | Alginate biosynthesis regulatory protein; Function of homologous gene experimentally demonstrated in an other organism; regulator. | 0.550 |
PSEEN5350 | hemC | PSEEN5350 | PSEEN5353 | Putative hemY protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; factor. | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.812 |
PSEEN5350 | hemD | PSEEN5350 | PSEEN5352 | Putative hemY protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; factor. | Uroporphyrinogen III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | 0.877 |
PSEEN5351 | PSEEN5350 | PSEEN5351 | PSEEN5350 | Putative uroporphyrin-III C-methyltransferase HemX; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. | Putative hemY protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; factor. | 0.979 |
PSEEN5351 | algR | PSEEN5351 | PSEEN5354 | Putative uroporphyrin-III C-methyltransferase HemX; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. | Alginate biosynthesis regulatory protein; Function of homologous gene experimentally demonstrated in an other organism; regulator. | 0.550 |
PSEEN5351 | cysG | PSEEN5351 | PSEEN2217 | Putative uroporphyrin-III C-methyltransferase HemX; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. | Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | 0.917 |
PSEEN5351 | hemC | PSEEN5351 | PSEEN5353 | Putative uroporphyrin-III C-methyltransferase HemX; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.853 |
PSEEN5351 | hemD | PSEEN5351 | PSEEN5352 | Putative uroporphyrin-III C-methyltransferase HemX; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. | Uroporphyrinogen III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | 0.992 |
PSEEN5351 | hemE | PSEEN5351 | PSEEN0339 | Putative uroporphyrin-III C-methyltransferase HemX; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.910 |
algR | PSEEN5350 | PSEEN5354 | PSEEN5350 | Alginate biosynthesis regulatory protein; Function of homologous gene experimentally demonstrated in an other organism; regulator. | Putative hemY protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; factor. | 0.550 |
algR | PSEEN5351 | PSEEN5354 | PSEEN5351 | Alginate biosynthesis regulatory protein; Function of homologous gene experimentally demonstrated in an other organism; regulator. | Putative uroporphyrin-III C-methyltransferase HemX; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. | 0.550 |
algR | hemC | PSEEN5354 | PSEEN5353 | Alginate biosynthesis regulatory protein; Function of homologous gene experimentally demonstrated in an other organism; regulator. | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.597 |
algR | hemD | PSEEN5354 | PSEEN5352 | Alginate biosynthesis regulatory protein; Function of homologous gene experimentally demonstrated in an other organism; regulator. | Uroporphyrinogen III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | 0.617 |
cysG | PSEEN3126 | PSEEN2217 | PSEEN3126 | Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | Putative ferredoxin reductase component; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. | 0.946 |
cysG | PSEEN5351 | PSEEN2217 | PSEEN5351 | Siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | Putative uroporphyrin-III C-methyltransferase HemX; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. | 0.917 |