| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| PSEEN5437 | birA | PSEEN5437 | PSEEN0471 | Putative catabolite repression control protein Crc; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; factor. | Putative biotin-[acetylCoA carboxylase] holoenzyme synthetase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | 0.794 |
| PSEEN5437 | crbA | PSEEN5437 | PSEEN4729 | Putative catabolite repression control protein Crc; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; factor. | Sensory box histidine kinase CrbA; Function of homologous gene experimentally demonstrated in an other organism; regulator. | 0.648 |
| PSEEN5437 | dnaN | PSEEN5437 | PSEEN0002 | Putative catabolite repression control protein Crc; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; factor. | DNA polymerase III, beta chain; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of r [...] | 0.787 |
| PSEEN5437 | hfq | PSEEN5437 | PSEEN4943 | Putative catabolite repression control protein Crc; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; factor. | Hfq protein; RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs. Belongs to the Hfq family. | 0.951 |
| PSEEN5437 | mutY | PSEEN5437 | PSEEN5199 | Putative catabolite repression control protein Crc; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; factor. | A/G specific adenine glycosylase; Adenine glycosylase active on G-A mispairs. | 0.771 |
| PSEEN5437 | nth | PSEEN5437 | PSEEN1214 | Putative catabolite repression control protein Crc; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; factor. | Endonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. | 0.965 |
| PSEEN5437 | polA | PSEEN5437 | PSEEN0076 | Putative catabolite repression control protein Crc; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; factor. | DNA polymerase I, 3'--> 5' polymerase, 5'--> 3' and 3'--> 5' exonuclease; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.756 |
| PSEEN5437 | pyrE | PSEEN5437 | PSEEN5436 | Putative catabolite repression control protein Crc; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; factor. | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). | 0.768 |
| PSEEN5437 | ung | PSEEN5437 | PSEEN4312 | Putative catabolite repression control protein Crc; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; factor. | uracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine. | 0.648 |
| PSEEN5437 | xthA | PSEEN5437 | PSEEN2076 | Putative catabolite repression control protein Crc; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; factor. | Exonuclease III; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.919 |
| birA | PSEEN5437 | PSEEN0471 | PSEEN5437 | Putative biotin-[acetylCoA carboxylase] holoenzyme synthetase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | Putative catabolite repression control protein Crc; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; factor. | 0.794 |
| birA | hfq | PSEEN0471 | PSEEN4943 | Putative biotin-[acetylCoA carboxylase] holoenzyme synthetase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | Hfq protein; RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs. Belongs to the Hfq family. | 0.638 |
| birA | mutY | PSEEN0471 | PSEEN5199 | Putative biotin-[acetylCoA carboxylase] holoenzyme synthetase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | A/G specific adenine glycosylase; Adenine glycosylase active on G-A mispairs. | 0.432 |
| birA | nth | PSEEN0471 | PSEEN1214 | Putative biotin-[acetylCoA carboxylase] holoenzyme synthetase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | Endonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. | 0.457 |
| birA | xthA | PSEEN0471 | PSEEN2076 | Putative biotin-[acetylCoA carboxylase] holoenzyme synthetase; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | Exonuclease III; Function of homologous gene experimentally demonstrated in an other organism; enzyme. | 0.794 |
| crbA | PSEEN5437 | PSEEN4729 | PSEEN5437 | Sensory box histidine kinase CrbA; Function of homologous gene experimentally demonstrated in an other organism; regulator. | Putative catabolite repression control protein Crc; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; factor. | 0.648 |
| crbA | dnaN | PSEEN4729 | PSEEN0002 | Sensory box histidine kinase CrbA; Function of homologous gene experimentally demonstrated in an other organism; regulator. | DNA polymerase III, beta chain; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of r [...] | 0.416 |
| crbA | hfq | PSEEN4729 | PSEEN4943 | Sensory box histidine kinase CrbA; Function of homologous gene experimentally demonstrated in an other organism; regulator. | Hfq protein; RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs. Belongs to the Hfq family. | 0.643 |
| dnaN | PSEEN5437 | PSEEN0002 | PSEEN5437 | DNA polymerase III, beta chain; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of r [...] | Putative catabolite repression control protein Crc; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; factor. | 0.787 |
| dnaN | crbA | PSEEN0002 | PSEEN4729 | DNA polymerase III, beta chain; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of r [...] | Sensory box histidine kinase CrbA; Function of homologous gene experimentally demonstrated in an other organism; regulator. | 0.416 |