STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pfpPhosphofructokinase domain protein; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions. (420 aa)    
Predicted Functional Partners:
pgi
Glucose-6-phosphate isomerase 2; Belongs to the GPI family.
  
 0.992
Q91_0742
Pyruvate kinase II; Belongs to the pyruvate kinase family.
 
 
 0.957
guaA
Bifunctional GMP synthase/glutamine amidotransferase protein; Catalyzes the synthesis of GMP from XMP.
   
  
 0.955
fbaA
Fructose-bisphosphate aldolase, class II, Calvin cycle subtype; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.
  
 
 0.953
tktA
Transketolase 1; Belongs to the transketolase family.
  
 
 0.940
eno
Enolase 2; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.
  
  
 0.922
tpiA
Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family.
  
  
 0.881
pgk
Phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family.
  
  
 0.800
Q91_1355
AMP-dependent synthetase and ligase.
  
 
 0.570
Q91_0522
Malate dehydrogenase, Phosphate acetyltransferase.
  
  
 0.541
Your Current Organism:
Cycloclasticus sp. P1
NCBI taxonomy Id: 385025
Other names: C. sp. P1
Server load: medium (48%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.