SFE51565.1 protein (Thermophagus xiamenensis)

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Known Interactions

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Predicted Interactions

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Score

SFE51565.1

Aspartate aminotransferase. (398 aa)

Predicted Functional Partners:

SFF04761.1

0.948

SFD80256.1

0.901

SFD69907.1

0.897

SFD94948.1

0.866

SFD72078.1

0.728

SFE19032.1

0.723

SFF10249.1

0.723

SFE43210.1

0.716

SFD69756.1

0.713

asnA

0.706

Your Current Organism:

Thermophagus xiamenensis

NCBI taxonomy Id: 385682
Other names: Anaerophaga sp. HS1, CGMCC 1.5071, DSM 19012, Marinilabiaceae bacterium HS1, T. xiamenensis, Thermophagus xiamenensis Gao et al. 2013, strain HS1

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
SFD69756.1	SFD80256.1	SAMN05444380_10167	SAMN05444380_102109	Aspartate ammonia-lyase.	Pyruvate-ferredoxin/flavodoxin oxidoreductase.	0.931
SFD69756.1	SFD94948.1	SAMN05444380_10167	SAMN05444380_104122	Aspartate ammonia-lyase.	Aspartate kinase.	0.777
SFD69756.1	SFE51565.1	SAMN05444380_10167	SAMN05444380_112105	Aspartate ammonia-lyase.	Aspartate aminotransferase.	0.713
SFD69907.1	SFD72078.1	SAMN05444380_10172	SAMN05444380_101135	Glutamate synthase (NADPH/NADH) large chain.	Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.	0.493
SFD69907.1	SFD80256.1	SAMN05444380_10172	SAMN05444380_102109	Glutamate synthase (NADPH/NADH) large chain.	Pyruvate-ferredoxin/flavodoxin oxidoreductase.	0.943
SFD69907.1	SFD94948.1	SAMN05444380_10172	SAMN05444380_104122	Glutamate synthase (NADPH/NADH) large chain.	Aspartate kinase.	0.761
SFD69907.1	SFE19032.1	SAMN05444380_10172	SAMN05444380_1086	Glutamate synthase (NADPH/NADH) large chain.	Aspartate kinase; Belongs to the aspartokinase family.	0.424
SFD69907.1	SFE51565.1	SAMN05444380_10172	SAMN05444380_112105	Glutamate synthase (NADPH/NADH) large chain.	Aspartate aminotransferase.	0.897
SFD69907.1	SFF10249.1	SAMN05444380_10172	SAMN05444380_1413	Glutamate synthase (NADPH/NADH) large chain.	Aspartate kinase; Belongs to the aspartokinase family.	0.424
SFD72078.1	SFD69907.1	SAMN05444380_101135	SAMN05444380_10172	Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.	Glutamate synthase (NADPH/NADH) large chain.	0.493
SFD72078.1	SFD80256.1	SAMN05444380_101135	SAMN05444380_102109	Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.	Pyruvate-ferredoxin/flavodoxin oxidoreductase.	0.921
SFD72078.1	SFD94948.1	SAMN05444380_101135	SAMN05444380_104122	Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.	Aspartate kinase.	0.966
SFD72078.1	SFE19032.1	SAMN05444380_101135	SAMN05444380_1086	Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.	Aspartate kinase; Belongs to the aspartokinase family.	0.830
SFD72078.1	SFE51565.1	SAMN05444380_101135	SAMN05444380_112105	Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.	Aspartate aminotransferase.	0.728
SFD72078.1	SFF10249.1	SAMN05444380_101135	SAMN05444380_1413	Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.	Aspartate kinase; Belongs to the aspartokinase family.	0.830
SFD80256.1	SFD69756.1	SAMN05444380_102109	SAMN05444380_10167	Pyruvate-ferredoxin/flavodoxin oxidoreductase.	Aspartate ammonia-lyase.	0.931
SFD80256.1	SFD69907.1	SAMN05444380_102109	SAMN05444380_10172	Pyruvate-ferredoxin/flavodoxin oxidoreductase.	Glutamate synthase (NADPH/NADH) large chain.	0.943
SFD80256.1	SFD72078.1	SAMN05444380_102109	SAMN05444380_101135	Pyruvate-ferredoxin/flavodoxin oxidoreductase.	Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.	0.921
SFD80256.1	SFD94948.1	SAMN05444380_102109	SAMN05444380_104122	Pyruvate-ferredoxin/flavodoxin oxidoreductase.	Aspartate kinase.	0.692
SFD80256.1	SFE51565.1	SAMN05444380_102109	SAMN05444380_112105	Pyruvate-ferredoxin/flavodoxin oxidoreductase.	Aspartate aminotransferase.	0.901

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

48

average node degree:

8.73

avg. local clustering coefficient:

0.933

expected number of edges:

11

PPI enrichment p-value:

1.11e-16

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0008299

Isoprenoid biosynthetic process

9 of 27

2.8

9.97

2.02e-20

GO:0016126

Sterol biosynthetic process

7 of 37

2.55

6.68

3.71e-14

GO:0046165

Alcohol biosynthetic process

8 of 87

2.24

6.02

3.00e-14

GO:1901617

Organic hydroxy compound biosynthetic process

9 of 132

2.11

5.91

3.32e-15

GO:0006695

Cholesterol biosynthetic process

6 of 27

2.62

5.84

3.98e-12

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004659

Prenyltransferase activity

4 of 15

2.7

3.57

2.14e-07

GO:0016765

Transferase activity, transferring alkyl or aryl (other than methyl) groups

5 of 49

2.29

3.46

1.16e-07

GO:0004337

Geranyltranstransferase activity

2 of 3

3.1

1.53

0.0017

GO:0004161

Dimethylallyltranstransferase activity

2 of 3

3.1

1.53

0.0017

GO:0016709

Oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

2 of 23

2.22

0.8

0.0333

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:1904423

Dehydrodolichyl diphosphate synthase complex

2 of 2

3.28

1.51

0.0019

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:5410

Isoprenoid biosynthetic process

8 of 15

3.0

9.98

1.04e-19

CL:5304

Steroid biosynthetic process, and Prenyltransferase activity

11 of 78

2.43

9.91

2.05e-23

CL:5413

Terpenoid backbone biosynthesis

7 of 8

3.22

9.37

4.27e-18

CL:5316

Steroid biosynthesis, and 3-beta hydroxysteroid dehydrogenase/isomerase family

3 of 21

2.43

2.07

0.00013

CL:5319

Steroid biosynthesis

2 of 8

2.68

1.32

0.0040

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

hcq00900

Terpenoid backbone biosynthesis

7 of 19

2.84

8.3

1.05e-16

hcq00100

Steroid biosynthesis

3 of 23

2.39

2.52

1.56e-05

hcq01100

Metabolic pathways

9 of 1363

1.1

1.38

9.08e-08

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-191273

Cholesterol biosynthesis

8 of 31

2.69

8.39

1.89e-17

MAP-8957322

Metabolism of steroids

8 of 165

1.96

4.58

2.55e-12

MAP-446199

Synthesis of Dolichyl-phosphate

3 of 6

2.98

2.97

3.80e-06

MAP-556833

Metabolism of lipids

8 of 948

1.2

1.48

1.53e-06

MAP-446219

Synthesis of substrates in N-glycan biosythesis

3 of 86

1.82

1.23

0.0034

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:1904423

Dehydrodolichyl diphosphate synthase complex

2 of 5

2.88

1.16

0.0080

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0756

Sterol biosynthesis

2 of 4

2.98

1.61

0.0012

KW-0752

Steroid biosynthesis

2 of 4

2.98

1.61

0.0012

KW-0808

Transferase

5 of 961

0.99

0.73

0.0051

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF01255

Putative undecaprenyl diphosphate synthase

2 of 2

3.28

1.37

0.0034

PF00348

Polyprenyl synthetase

2 of 4

2.98

1.31

0.0043

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR036424

Decaprenyl diphosphate synthase-like superfamily

2 of 2

3.28

1.1

0.0106

IPR033749

Polyprenyl synthetase, conserved site

2 of 3

3.1

1.1

0.0106

IPR000092

Polyprenyl synthetase

2 of 4

2.98

1.09

0.0106

IPR008949

Isoprenoid synthase domain superfamily

2 of 6

2.8

1.06

0.0123

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