node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SFE73708.1 | SFE99473.1 | SAMN05444380_11762 | SAMN05444380_12612 | 6-pyruvoyltetrahydropterin/6- carboxytetrahydropterin synthase. | 7-cyano-7-deazaguanine reductase; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily. | 0.689 |
SFE73708.1 | queC | SAMN05444380_11762 | SAMN05444380_12541 | 6-pyruvoyltetrahydropterin/6- carboxytetrahydropterin synthase. | preQ(0) biosynthesis protein QueC; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. | 0.956 |
SFE73708.1 | queE | SAMN05444380_11762 | SAMN05444380_12540 | 6-pyruvoyltetrahydropterin/6- carboxytetrahydropterin synthase. | 7-carboxy-7-deazaguanine synthase; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. | 0.989 |
SFE99448.1 | SFE99473.1 | SAMN05444380_12611 | SAMN05444380_12612 | 23S rRNA (uracil1939-C5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. | 7-cyano-7-deazaguanine reductase; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily. | 0.539 |
SFE99448.1 | SFE99501.1 | SAMN05444380_12611 | SAMN05444380_12613 | 23S rRNA (uracil1939-C5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. | tRNA 2-selenouridine synthase. | 0.439 |
SFE99448.1 | SFE99531.1 | SAMN05444380_12611 | SAMN05444380_12614 | 23S rRNA (uracil1939-C5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. | Selenium metabolism protein YedF; Belongs to the sulfur carrier protein TusA family. | 0.439 |
SFE99448.1 | SFE99562.1 | SAMN05444380_12611 | SAMN05444380_12615 | 23S rRNA (uracil1939-C5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. | Cysteine desulfurase family protein. | 0.439 |
SFE99448.1 | SFE99593.1 | SAMN05444380_12611 | SAMN05444380_12616 | 23S rRNA (uracil1939-C5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. | Protein of unknown function. | 0.423 |
SFE99473.1 | SFE73708.1 | SAMN05444380_12612 | SAMN05444380_11762 | 7-cyano-7-deazaguanine reductase; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily. | 6-pyruvoyltetrahydropterin/6- carboxytetrahydropterin synthase. | 0.689 |
SFE99473.1 | SFE99448.1 | SAMN05444380_12612 | SAMN05444380_12611 | 7-cyano-7-deazaguanine reductase; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily. | 23S rRNA (uracil1939-C5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. | 0.539 |
SFE99473.1 | SFE99501.1 | SAMN05444380_12612 | SAMN05444380_12613 | 7-cyano-7-deazaguanine reductase; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily. | tRNA 2-selenouridine synthase. | 0.615 |
SFE99473.1 | SFE99531.1 | SAMN05444380_12612 | SAMN05444380_12614 | 7-cyano-7-deazaguanine reductase; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily. | Selenium metabolism protein YedF; Belongs to the sulfur carrier protein TusA family. | 0.615 |
SFE99473.1 | SFE99562.1 | SAMN05444380_12612 | SAMN05444380_12615 | 7-cyano-7-deazaguanine reductase; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily. | Cysteine desulfurase family protein. | 0.615 |
SFE99473.1 | SFE99593.1 | SAMN05444380_12612 | SAMN05444380_12616 | 7-cyano-7-deazaguanine reductase; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily. | Protein of unknown function. | 0.591 |
SFE99473.1 | queA | SAMN05444380_12612 | SAMN05444380_11242 | 7-cyano-7-deazaguanine reductase; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily. | S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). | 0.413 |
SFE99473.1 | queC | SAMN05444380_12612 | SAMN05444380_12541 | 7-cyano-7-deazaguanine reductase; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily. | preQ(0) biosynthesis protein QueC; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. | 0.962 |
SFE99473.1 | queE | SAMN05444380_12612 | SAMN05444380_12540 | 7-cyano-7-deazaguanine reductase; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily. | 7-carboxy-7-deazaguanine synthase; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. | 0.869 |
SFE99473.1 | tgt | SAMN05444380_12612 | SAMN05444380_11127 | 7-cyano-7-deazaguanine reductase; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily. | tRNA-guanine transglycosylase; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, - Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the [...] | 0.577 |
SFE99501.1 | SFE99448.1 | SAMN05444380_12613 | SAMN05444380_12611 | tRNA 2-selenouridine synthase. | 23S rRNA (uracil1939-C5)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. | 0.439 |
SFE99501.1 | SFE99473.1 | SAMN05444380_12613 | SAMN05444380_12612 | tRNA 2-selenouridine synthase. | 7-cyano-7-deazaguanine reductase; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily. | 0.615 |