Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
TP73LOW QUALITY PROTEIN: tumor protein p73. (656 aa)    
Predicted Functional Partners:
TP53
Cellular tumor antigen p53.
  
 
0.997
YAP1
Transcriptional coactivator YAP1 isoform X1.
    
 0.983
WWTR1
WW domain-containing transcription regulator protein 1.
    
 0.983
ITCH
E3 ubiquitin-protein ligase Itchy homolog.
    
 0.966
MDM2
LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase Mdm2.
   
 0.956
TP63
Tumor protein 63-like.
    
 0.953
EP300
E1A binding protein p300.
    
 0.934
MDM4
Protein Mdm4 isoform X1.
   
 0.902
ENSPCIP00000043722
annotation not available
   
 0.893
ENSPCIP00000052893
Interleukin-10 receptor subunit beta-like.
    
 0.824
Your Current Organism:
Phascolarctos cinereus
NCBI taxonomy Id: 38626
Other names: P. cinereus, koala
Server load: low (12%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.