CDPF1 protein (Phascolarctos cinereus) - STRING interaction network

Nodes:

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second shell of interactors

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Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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CDPF1

Cysteine-rich DPF motif domain-containing protein 1. (123 aa)

Predicted Functional Partners:

DNLZ

0.563

ATXN10

0.556

PKDREJ

0.520

WDR89

0.475

ENSPCIP00000049195

0.472

PSMD9

0.424

Your Current Organism:

Phascolarctos cinereus

NCBI taxonomy Id: 38626
Other names: P. cinereus, koala

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATXN10	CDPF1	ENSPCIP00000019249	ENSPCIP00000008335	Ataxin-10 isoform X1.	Cysteine-rich DPF motif domain-containing protein 1.	0.556
CDPF1	ATXN10	ENSPCIP00000008335	ENSPCIP00000019249	Cysteine-rich DPF motif domain-containing protein 1.	Ataxin-10 isoform X1.	0.556
CDPF1	DNLZ	ENSPCIP00000008335	ENSPCIP00000006019	Cysteine-rich DPF motif domain-containing protein 1.	Mitochondrial protein import protein ZIM17.	0.563
CDPF1	ENSPCIP00000049195	ENSPCIP00000008335	ENSPCIP00000049195	Cysteine-rich DPF motif domain-containing protein 1.	annotation not available	0.472
CDPF1	PKDREJ	ENSPCIP00000008335	ENSPCIP00000031837	Cysteine-rich DPF motif domain-containing protein 1.	Polycystic kidney disease and receptor for egg jelly-related protein.	0.520
CDPF1	PSMD9	ENSPCIP00000008335	ENSPCIP00000038922	Cysteine-rich DPF motif domain-containing protein 1.	26S proteasome non-ATPase regulatory subunit 9.	0.424
CDPF1	WDR89	ENSPCIP00000008335	ENSPCIP00000008709	Cysteine-rich DPF motif domain-containing protein 1.	WD repeat-containing protein 89.	0.475
DNLZ	CDPF1	ENSPCIP00000006019	ENSPCIP00000008335	Mitochondrial protein import protein ZIM17.	Cysteine-rich DPF motif domain-containing protein 1.	0.563
DNLZ	ENSPCIP00000049195	ENSPCIP00000006019	ENSPCIP00000049195	Mitochondrial protein import protein ZIM17.	annotation not available	0.472
DNLZ	PSMD9	ENSPCIP00000006019	ENSPCIP00000038922	Mitochondrial protein import protein ZIM17.	26S proteasome non-ATPase regulatory subunit 9.	0.418
DNLZ	WDR89	ENSPCIP00000006019	ENSPCIP00000008709	Mitochondrial protein import protein ZIM17.	WD repeat-containing protein 89.	0.475
ENSPCIP00000049195	CDPF1	ENSPCIP00000049195	ENSPCIP00000008335	annotation not available	Cysteine-rich DPF motif domain-containing protein 1.	0.472
ENSPCIP00000049195	DNLZ	ENSPCIP00000049195	ENSPCIP00000006019	annotation not available	Mitochondrial protein import protein ZIM17.	0.472
PKDREJ	CDPF1	ENSPCIP00000031837	ENSPCIP00000008335	Polycystic kidney disease and receptor for egg jelly-related protein.	Cysteine-rich DPF motif domain-containing protein 1.	0.520
PSMD9	CDPF1	ENSPCIP00000038922	ENSPCIP00000008335	26S proteasome non-ATPase regulatory subunit 9.	Cysteine-rich DPF motif domain-containing protein 1.	0.424
PSMD9	DNLZ	ENSPCIP00000038922	ENSPCIP00000006019	26S proteasome non-ATPase regulatory subunit 9.	Mitochondrial protein import protein ZIM17.	0.418
WDR89	CDPF1	ENSPCIP00000008709	ENSPCIP00000008335	WD repeat-containing protein 89.	Cysteine-rich DPF motif domain-containing protein 1.	0.475
WDR89	DNLZ	ENSPCIP00000008709	ENSPCIP00000006019	WD repeat-containing protein 89.	Mitochondrial protein import protein ZIM17.	0.475

Network Stats

number of nodes:

11

number of edges:

20

average node degree:

3.64

avg. local clustering coefficient:

0.823

expected number of edges:

13

PPI enrichment p-value:

0.0551

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0030433

Ubiquitin-dependent ERAD pathway

5 of 66

2.17

3.32

1.41e-07

GO:0043161

Proteasome-mediated ubiquitin-dependent protein catabolic process

8 of 278

1.75

3.27

1.18e-09

GO:0030970

Retrograde protein transport, ER to cytosol

3 of 12

2.69

2.54

2.04e-05

GO:0035967

Cellular response to topologically incorrect protein

4 of 89

1.94

2.09

4.33e-05

GO:0071712

ER-associated misfolded protein catabolic process

2 of 8

2.69

1.4

0.0028

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0043130

Ubiquitin binding

4 of 80

1.99

1.85

0.00019

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0034098

VCP-NPL4-UFD1 AAA ATPase complex

5 of 6

3.21

6.08

7.11e-12

GO:0140534

Endoplasmic reticulum protein-containing complex

6 of 94

2.09

3.91

2.53e-09

GO:0005789

Endoplasmic reticulum membrane

6 of 849

1.14

1.01

0.00065

GO:0098796

Membrane protein complex

6 of 1140

1.01

0.83

0.0015

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:8599

Mixed, incl. Domain present in ubiquitin-regulatory proteins, and Josephin domain DUBs

6 of 20

2.77

6.29

9.29e-13

CL:8556

Mixed, incl. ERAD pathway, and Preribosome binding

7 of 42

2.51

6.19

3.23e-13

CL:8601

Domain present in ubiquitin-regulatory proteins, and Cell division protein 48 (CDC48) N-terminal domain

4 of 12

2.81

3.91

5.34e-08

CL:8615

UAS, and Cell division protein 48 (CDC48) N-terminal domain

3 of 5

3.07

2.98

3.77e-06

CL:8069

VCP-NPL4-UFD1 AAA ATPase complex, and Microtubule severing

3 of 5

3.07

2.98

3.77e-06

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

tru04141

Protein processing in endoplasmic reticulum

6 of 165

1.85

3.18

1.77e-08

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-9755511

KEAP1-NFE2L2 pathway

5 of 106

1.96

2.6

2.56e-06

MAP-110320

Translesion Synthesis by POLH

3 of 29

2.3

1.88

0.00027

MAP-9711123

Cellular response to chemical stress

5 of 217

1.65

1.85

4.18e-05

MAP-8951664

Neddylation

5 of 362

1.43

1.39

0.00027

MAP-110313

Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template

3 of 75

1.89

1.31

0.0025

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0034098

VCP-NPL4-UFD1 AAA ATPase complex

4 of 6

3.11

4.33

1.20e-08

GOCC:0036501

UFD1-NPL4 complex

2 of 2

3.29

1.81

0.00054

GOCC:0005789

Endoplasmic reticulum membrane

5 of 307

1.5

1.49

0.00021

GOCC:0005783

Endoplasmic reticulum

5 of 581

1.22

1.0

0.0018

GOCC:0098796

Membrane protein complex

5 of 930

1.02

0.66

0.0126

(more ...)

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF14555

UBA-like domain

3 of 15

2.59

2.01

0.00019

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR006577

UAS

2 of 3

3.11

1.02

0.0146

IPR001012

UBX domain

2 of 10

2.59

0.73

0.0481

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00594

UAS

3 of 4

3.16

3.07

2.74e-06

SM00166

Domain present in ubiquitin-regulatory proteins

3 of 9

2.81

2.76

8.61e-06

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