Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
TOP2BDNA topoisomerase 2-beta isoform X1. (1633 aa)    
Predicted Functional Partners:
TOP2A
DNA topoisomerase 2-alpha.
  
 
0.996
CDK1
Cyclin-dependent kinase 1.
   
 
 0.922
CENPF
Centromere protein F.
   
  
 0.867
SMC2
Structural maintenance of chromosomes protein 2 isoform X1.
   
 
 0.859
PLK1
Serine/threonine-protein kinase PLK1.
   
 
 0.850
DLGAP5
Disks large-associated protein 5 isoform X1.
   
  
 0.841
TOP1MT
DNA topoisomerase I, mitochondrial isoform X1.
   
 
 0.821
BIRC5
Baculoviral IAP repeat-containing protein 5 isoform X1.
   
  
 0.820
NDC80
Kinetochore protein NDC80 homolog isoform X1.
   
 
 0.794
TOP1
DNA topoisomerase 1 isoform X1.
   
 
 0.790
Your Current Organism:
Phascolarctos cinereus
NCBI taxonomy Id: 38626
Other names: P. cinereus, koala
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