STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
HECW2LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase HECW2. (1546 aa)    
Predicted Functional Partners:
DVL1
Dishevelled segment polarity protein 1.
    
 0.870
SMAD6
Mothers against decapentaplegic homolog 6.
    
 0.615
SMAD7
Mothers against decapentaplegic homolog 7.
    
 0.615
GJA1
Gap junction alpha-1 protein.
    
 0.602
UBE2K
Ubiquitin-conjugating enzyme (huntingtin interacting protein 2).
    
 0.601
SGK2
Serine/threonine-protein kinase Sgk2 isoform X1.
   
 0.593
SGK1
Serum/glucocorticoid regulated kinase 1.
   
 0.593
ISG15
Ubiquitin cross-reactive protein.
    
 0.588
SMURF1
E3 ubiquitin-protein ligase SMURF1 isoform X1.
    
 0.582
ARRDC1
Arrestin domain-containing protein 1 isoform X1.
    
 
 0.580
Your Current Organism:
Phascolarctos cinereus
NCBI taxonomy Id: 38626
Other names: P. cinereus, koala
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.