Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
DTX4E3 ubiquitin-protein ligase DTX4. (622 aa)    
Predicted Functional Partners:
NOTCH1
LOW QUALITY PROTEIN: neurogenic locus notch homolog protein 1.
    
 0.968
NOTCH3
Neurogenic locus notch homolog protein 3 isoform X1.
    
 0.867
NOTCH2
LOW QUALITY PROTEIN: neurogenic locus notch homolog protein 2.
    
 0.858
ITCH
E3 ubiquitin-protein ligase Itchy homolog.
    
 0.835
NOTCH4
Neurogenic locus notch homolog protein 4.
    
 0.823
WWP1
LOW QUALITY PROTEIN: NEDD4-like E3 ubiquitin-protein ligase WWP1.
    
 0.705
WWP2
LOW QUALITY PROTEIN: NEDD4-like E3 ubiquitin-protein ligase WWP2.
    
 0.705
RBPJ
Recombining binding protein suppressor of hairless isoform X1.
   
 
 0.509
NUDCD1
NudC domain-containing protein 1 isoform X1.
    
   0.456
HECW2
LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase HECW2.
    
 0.452
Your Current Organism:
Phascolarctos cinereus
NCBI taxonomy Id: 38626
Other names: P. cinereus, koala
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