Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
CD276Immune costimulatory protein B7-H3. (314 aa)    
Predicted Functional Partners:
CD28
T-cell-specific surface glycoprotein CD28.
      
 0.631
CD4
T-cell surface glycoprotein CD4.
     
 0.617
CD8A
T-cell surface glycoprotein CD8 alpha chain.
      
 0.617
CTLA4
Cytotoxic T-lymphocyte-associated protein 4.
      
 0.561
ICOS
Inducible T-cell co-stimulator.
      
 0.559
PDCD1
Programmed cell death protein 1 isoform X1.
      
 0.548
TNFRSF9
Tumor necrosis factor receptor superfamily member 9.
      
 0.546
IFNG
Interferon gamma isoform X1.
      
 0.546
DONSON
Protein downstream neighbor of Son isoform X1.
      
 0.539
ENSPCIP00000005750
annotation not available
    
 0.534
Your Current Organism:
Phascolarctos cinereus
NCBI taxonomy Id: 38626
Other names: P. cinereus, koala
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.