Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
FOXO3Forkhead box protein O3. (689 aa)    
Predicted Functional Partners:
SIRT1
LOW QUALITY PROTEIN: NAD-dependent protein deacetylase sirtuin-1.
    
 0.992
AKT3
AKT serine/threonine kinase 3.
    
 0.969
AKT1
AKT serine/threonine kinase 1.
    
 0.969
AKT2
RAC-beta serine/threonine-protein kinase.
    
 0.969
SMAD3
Mothers against decapentaplegic homolog 3.
    
 0.967
SMAD2
Mothers against decapentaplegic homolog 2 isoform X1.
    
 0.967
USP7
Ubiquitin carboxyl-terminal hydrolase 7.
   
 0.967
IKBKB
Inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1.
    
 0.965
YWHAZ
14-3-3 protein beta/theta/zeta.
    
 0.964
YWHAQ
14-3-3 protein beta/theta/zeta.
    
 0.961
Your Current Organism:
Phascolarctos cinereus
NCBI taxonomy Id: 38626
Other names: P. cinereus, koala
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