STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
NPC1Niemann-Pick C1 protein isoform X1. (1285 aa)    
Predicted Functional Partners:
NPC2
Epididymal secretory protein E1.
   
 0.999
OSBPL5
Oxysterol-binding protein-related protein 5 isoform X1.
   
 0.971
SREBF2
Sterol regulatory element-binding transcription factor 2.
   
 0.872
SREBF1
Sterol regulatory element binding transcription factor 1.
   
 0.825
MYCN
MYCN proto-oncogene, bHLH transcription factor.
   
 0.771
GTPBP1
GTP-binding protein 1 isoform X1.
   
  
 0.710
GP2
Pancreatic secretory granule membrane major glycoprotein GP2.
   
  
 0.687
INSIG1
Insulin-induced gene 1 protein.
   
 0.685
INSIG2
Insulin-induced gene 2 protein.
   
 0.685
TMEM97
Transmembrane protein 97.
      
 0.666
Your Current Organism:
Phascolarctos cinereus
NCBI taxonomy Id: 38626
Other names: P. cinereus, koala
Server load: low (30%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.