ITIH5 protein (Phascolarctos cinereus) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

Experiments

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[Homology]

Score

ITIH5

Inter-alpha-trypsin inhibitor heavy chain H5 isoform X1. (949 aa)

Predicted Functional Partners:

COQ3

0.841

PPOX

0.769

GMPS

0.693

ITIH3

0.602

ITIH1

0.530

COQ2

0.515

ENSPCIP00000015203

0.509

ENSPCIP00000040636

0.509

NT5E

0.509

EPHX2

0.476

Your Current Organism:

Phascolarctos cinereus

NCBI taxonomy Id: 38626
Other names: P. cinereus, koala

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
COQ2	COQ3	ENSPCIP00000027828	ENSPCIP00000000542	4-hydroxybenzoate polyprenyltransferase, mitochondrial.	Ubiquinone biosynthesis O-methyltransferase, mitochondrial isoform X1.	0.820
COQ2	ITIH5	ENSPCIP00000027828	ENSPCIP00000022848	4-hydroxybenzoate polyprenyltransferase, mitochondrial.	Inter-alpha-trypsin inhibitor heavy chain H5 isoform X1.	0.515
COQ3	COQ2	ENSPCIP00000000542	ENSPCIP00000027828	Ubiquinone biosynthesis O-methyltransferase, mitochondrial isoform X1.	4-hydroxybenzoate polyprenyltransferase, mitochondrial.	0.820
COQ3	EPHX2	ENSPCIP00000000542	ENSPCIP00000011530	Ubiquinone biosynthesis O-methyltransferase, mitochondrial isoform X1.	Epoxide hydrolase 2.	0.791
COQ3	ITIH5	ENSPCIP00000000542	ENSPCIP00000022848	Ubiquinone biosynthesis O-methyltransferase, mitochondrial isoform X1.	Inter-alpha-trypsin inhibitor heavy chain H5 isoform X1.	0.841
COQ3	PPOX	ENSPCIP00000000542	ENSPCIP00000050871	Ubiquinone biosynthesis O-methyltransferase, mitochondrial isoform X1.	Protoporphyrinogen/coproporphyrinogen III oxidase.	0.704
ENSPCIP00000015203	EPHX2	ENSPCIP00000015203	ENSPCIP00000011530	annotation not available	Epoxide hydrolase 2.	0.665
ENSPCIP00000015203	ITIH5	ENSPCIP00000015203	ENSPCIP00000022848	annotation not available	Inter-alpha-trypsin inhibitor heavy chain H5 isoform X1.	0.509
ENSPCIP00000015203	NT5E	ENSPCIP00000015203	ENSPCIP00000047251	annotation not available	LOW QUALITY PROTEIN: 5'-nucleotidase.	0.946
ENSPCIP00000040636	EPHX2	ENSPCIP00000040636	ENSPCIP00000011530	5'-nucleotidase-like.	Epoxide hydrolase 2.	0.665
ENSPCIP00000040636	GMPS	ENSPCIP00000040636	ENSPCIP00000000060	5'-nucleotidase-like.	GMP synthase (glutamine-hydrolysing).	0.915
ENSPCIP00000040636	ITIH5	ENSPCIP00000040636	ENSPCIP00000022848	5'-nucleotidase-like.	Inter-alpha-trypsin inhibitor heavy chain H5 isoform X1.	0.509
ENSPCIP00000040636	NT5E	ENSPCIP00000040636	ENSPCIP00000047251	5'-nucleotidase-like.	LOW QUALITY PROTEIN: 5'-nucleotidase.	0.909
EPHX2	COQ3	ENSPCIP00000011530	ENSPCIP00000000542	Epoxide hydrolase 2.	Ubiquinone biosynthesis O-methyltransferase, mitochondrial isoform X1.	0.791
EPHX2	ENSPCIP00000015203	ENSPCIP00000011530	ENSPCIP00000015203	Epoxide hydrolase 2.	annotation not available	0.665
EPHX2	ENSPCIP00000040636	ENSPCIP00000011530	ENSPCIP00000040636	Epoxide hydrolase 2.	5'-nucleotidase-like.	0.665
EPHX2	ITIH5	ENSPCIP00000011530	ENSPCIP00000022848	Epoxide hydrolase 2.	Inter-alpha-trypsin inhibitor heavy chain H5 isoform X1.	0.476
EPHX2	NT5E	ENSPCIP00000011530	ENSPCIP00000047251	Epoxide hydrolase 2.	LOW QUALITY PROTEIN: 5'-nucleotidase.	0.665
GMPS	ENSPCIP00000040636	ENSPCIP00000000060	ENSPCIP00000040636	GMP synthase (glutamine-hydrolysing).	5'-nucleotidase-like.	0.915
GMPS	ITIH5	ENSPCIP00000000060	ENSPCIP00000022848	GMP synthase (glutamine-hydrolysing).	Inter-alpha-trypsin inhibitor heavy chain H5 isoform X1.	0.693

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

54

average node degree:

9.82

avg. local clustering coefficient:

0.982

expected number of edges:

16

PPI enrichment p-value:

5.44e-14

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0015031

Protein transport

9 of 110

1.51

2.68

4.74e-10

GO:0044718

Siderophore transmembrane transport

3 of 20

1.77

1.29

0.0023

GO:0055085

Transmembrane transport

8 of 414

0.88

0.81

0.00015

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0031992

Energy transducer activity

3 of 4

2.47

2.12

0.00011

GO:0015343

Siderophore transmembrane transporter activity

3 of 28

1.63

0.97

0.0100

GO:0022857

Transmembrane transporter activity

9 of 432

0.92

0.9

3.60e-05

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0030288

Outer membrane-bounded periplasmic space

3 of 44

1.43

1.03

0.0042

GO:0005886

Plasma membrane

9 of 653

0.74

0.64

0.00023

GO:0016021

Integral component of membrane

9 of 967

0.57

0.44

0.0022

GO:0016020

Membrane

10 of 1384

0.46

0.37

0.0023

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:5771

Mixed, incl. TonB, C-terminal, and MotA/TolQ/ExbB proton channel

9 of 20

2.25

6.96

6.73e-17

CL:5772

Mixed, incl. MotA/TolQ/ExbB proton channel, and Energy transducer activity

7 of 13

2.33

5.82

3.74e-13

CL:5763

TonB-dependent receptor-like, beta-barrel domain superfamily, and Protein transport

11 of 63

1.84

5.22

1.49e-17

CL:5764

TonB-dependent receptor-like, beta-barrel domain superfamily, and Protein transport

10 of 56

1.85

5.01

4.05e-16

CL:5786

Mixed, incl. Putative MotA/TolQ/ExbB family protein, and Energy transducer activity

5 of 6

2.52

4.56

1.30e-09

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map01503

Cationic antimicrobial peptide (CAMP) resistance

5 of 88

1.35

1.33

0.00022

map02010

ABC transporters

5 of 166

1.08

0.86

0.0022

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0653

Protein transport

9 of 45

1.9

4.8

4.36e-14

KW-0735

Signal-anchor

3 of 5

2.38

2.25

5.28e-05

KW-0997

Cell inner membrane

3 of 81

1.17

0.59

0.0404

KW-0812

Transmembrane

9 of 949

0.57

0.44

0.0024

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF02472

Biopolymer transport protein ExbD/TolR

5 of 8

2.39

3.82

2.91e-08

PF03544

Gram-negative bacterial TonB protein C-terminal

3 of 7

2.23

1.75

0.00046

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR003400

Biopolymer transport protein ExbD/TolR

5 of 8

2.39

3.63

7.46e-08

IPR003538

Gram-negative bacterial TonB protein

3 of 4

2.47

1.86

0.00035

IPR037682

TonB, C-terminal

3 of 7

2.23

1.63

0.00079

IPR006260

TonB/TolA, C-terminal

3 of 7

2.23

1.63

0.00079

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