TTR protein (Phascolarctos cinereus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

TTR

Transthyretin. (149 aa)

Predicted Functional Partners:

RBP4

0.990

ENSPCIP00000008041

0.931

STRA6

0.854

GC

0.824

APP

0.772

APOA1

0.765

ENSPCIP00000020648

0.668

BCL3

0.667

INO80D

0.655

TMEM19

0.654

Your Current Organism:

Phascolarctos cinereus

NCBI taxonomy Id: 38626
Other names: P. cinereus, koala

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APOA1	APP	ENSPCIP00000032276	ENSPCIP00000034772	Apolipoprotein A-I.	Amyloid beta A4 protein isoform X1.	0.668
APOA1	ENSPCIP00000020648	ENSPCIP00000032276	ENSPCIP00000020648	Apolipoprotein A-I.	Alpha-1-antiproteinase-like isoform X1.	0.616
APOA1	RBP4	ENSPCIP00000032276	ENSPCIP00000050562	Apolipoprotein A-I.	Retinol-binding protein 4.	0.453
APOA1	TTR	ENSPCIP00000032276	ENSPCIP00000023067	Apolipoprotein A-I.	Transthyretin.	0.765
APP	APOA1	ENSPCIP00000034772	ENSPCIP00000032276	Amyloid beta A4 protein isoform X1.	Apolipoprotein A-I.	0.668
APP	TTR	ENSPCIP00000034772	ENSPCIP00000023067	Amyloid beta A4 protein isoform X1.	Transthyretin.	0.772
BCL3	TTR	ENSPCIP00000002274	ENSPCIP00000023067	B-cell lymphoma 3 protein isoform X1.	Transthyretin.	0.667
ENSPCIP00000008041	TTR	ENSPCIP00000008041	ENSPCIP00000023067	Uricase-like isoform X1.	Transthyretin.	0.931
ENSPCIP00000020648	APOA1	ENSPCIP00000020648	ENSPCIP00000032276	Alpha-1-antiproteinase-like isoform X1.	Apolipoprotein A-I.	0.616
ENSPCIP00000020648	GC	ENSPCIP00000020648	ENSPCIP00000010263	Alpha-1-antiproteinase-like isoform X1.	GC vitamin D binding protein.	0.583
ENSPCIP00000020648	TTR	ENSPCIP00000020648	ENSPCIP00000023067	Alpha-1-antiproteinase-like isoform X1.	Transthyretin.	0.668
GC	ENSPCIP00000020648	ENSPCIP00000010263	ENSPCIP00000020648	GC vitamin D binding protein.	Alpha-1-antiproteinase-like isoform X1.	0.583
GC	RBP4	ENSPCIP00000010263	ENSPCIP00000050562	GC vitamin D binding protein.	Retinol-binding protein 4.	0.665
GC	TTR	ENSPCIP00000010263	ENSPCIP00000023067	GC vitamin D binding protein.	Transthyretin.	0.824
INO80D	TTR	ENSPCIP00000049348	ENSPCIP00000023067	INO80 complex subunit D isoform X1.	Transthyretin.	0.655
RBP4	APOA1	ENSPCIP00000050562	ENSPCIP00000032276	Retinol-binding protein 4.	Apolipoprotein A-I.	0.453
RBP4	GC	ENSPCIP00000050562	ENSPCIP00000010263	Retinol-binding protein 4.	GC vitamin D binding protein.	0.665
RBP4	STRA6	ENSPCIP00000050562	ENSPCIP00000025384	Retinol-binding protein 4.	Stimulated by retinoic acid gene 6 protein homolog isoform X1.	0.900
RBP4	TTR	ENSPCIP00000050562	ENSPCIP00000023067	Retinol-binding protein 4.	Transthyretin.	0.990
STRA6	RBP4	ENSPCIP00000025384	ENSPCIP00000050562	Stimulated by retinoic acid gene 6 protein homolog isoform X1.	Retinol-binding protein 4.	0.900