STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
RB1Retinoblastoma-associated protein isoform X1. (927 aa)    
Predicted Functional Partners:
E2F1
Transcription factor E2F1.
   
 0.999
CDK4
Cyclin-dependent kinase 4.
   
 0.998
CDK2
Cyclin-dependent kinase 2 isoform X1.
   
 0.997
CCND1
G1/S-specific cyclin-D1.
    
 0.995
E2F2
Transcription factor E2F2 isoform X1.
   
 0.995
E2F3
Transcription factor E2F3 isoform X1.
   
 0.992
E2F4
Transcription factor E2F4/5.
   
 0.991
CCNA2
Cyclin-A2.
   
 0.990
CDK6
Cyclin-dependent kinase 6 isoform X1.
   
 0.990
MDM2
LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase Mdm2.
    
 0.989
Your Current Organism:
Phascolarctos cinereus
NCBI taxonomy Id: 38626
Other names: P. cinereus, koala
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.