STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
sucDsuccinyl-CoA synthetase (ADP-forming) alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (295 aa)    
Predicted Functional Partners:
sucC
succinyl-CoA synthetase (ADP-forming) beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
 0.999
SDK54069.1
Succinate dehydrogenase subunit B; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.
 
 0.991
SDK54037.1
Succinate dehydrogenase subunit A.
 
 0.989
SDK49697.1
2-oxoglutarate dehydrogenase E1 component.
 
 0.985
sdhC
Succinate dehydrogenase subunit C.
  
 
 0.977
gltB
Glutamate synthase (NADH) large subunit.
   
 
 0.971
SDK13511.1
2-oxoglutarate dehydrogenase E2 component.
 
 0.967
SDK54000.1
Succinate dehydrogenase / fumarate reductase membrane anchor subunit.
  
 
 0.926
SDK87371.1
Phosphotransacetylase.
  
 
 0.923
ldh
Malate dehydrogenase (NAD); Catalyzes the conversion of lactate to pyruvate. Belongs to the LDH/MDH superfamily. LDH family.
  
 0.894
Your Current Organism:
Cryobacterium psychrotolerans
NCBI taxonomy Id: 386301
Other names: C. psychrotolerans, CGMCC 1.5382, Cryobacterium psychrotolerans Zhang et al. 2007, Cryobacterium sp. 0549, JCM 13925, strain 0549
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.