STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
HIF1ANHypoxia-inducible factor 1-alpha inhibitor isoform X1. (395 aa)    
Predicted Functional Partners:
HIF1A
Hypoxia-inducible factor 1-alpha.
    
 0.958
TNKS2
Poly [ADP-ribose] polymerase.
    
 
 0.887
EPAS1
Endothelial PAS domain-containing protein 1 isoform X1.
    
 0.883
TRPA1
Transient receptor potential cation channel subfamily A member 1; Belongs to the transient receptor (TC 1.A.4) family.
    
   0.767
NOTCH1
Neurogenic locus notch homolog protein 1.
    
 
 0.694
LOC102379462
Protein eyes shut homolog.
    
 
 0.694
DUSP3
Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily.
      
 0.687
IL10RB
Interleukin-10 receptor subunit beta.
    
   0.663
TNKS
Poly [ADP-ribose] polymerase.
    
 
 0.622
SLC12A8
Solute carrier family 12 member 8 isoform X1.
      
 0.561
Your Current Organism:
Alligator sinensis
NCBI taxonomy Id: 38654
Other names: A. sinensis, Chinese alligator, MNHN 6494
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.