STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ORW70824.1Pup deamidase/depupylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (502 aa)    
Predicted Functional Partners:
pup
Ubiquitin; Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation.
 
  
 0.952
prcA
Proteasome subunit alpha; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. Belongs to the peptidase T1A family.
  
 0.952
prcB
Proteasome subunit beta; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. Belongs to the peptidase T1B family.
 
  
 0.949
arc
Proteasome ATPase; ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis.
 
  
 0.871
ORW70823.1
TetR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.
       0.701
ORW66268.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
   
 0.700
ORW64359.1
DNA-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
     
 0.691
ORW68715.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
     0.664
ORW66271.1
fatty-acid--CoA ligase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 0.624
ORW66382.1
Crp/Fnr family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
  
 0.546
Your Current Organism:
Mycolicibacter senuensis
NCBI taxonomy Id: 386913
Other names: DSM 44999, JCM 16017, KCTC 19147, M. senuensis, Mycobacterium senuense, Mycobacterium senuense Mun et al. 2008, Mycobacterium sp. 05-832, Mycolicibacter senuensis (Mun et al. 2008) Gupta et al. 2018, strain 05-832
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.