STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
egtAErgothioneine biosynthesis glutamate--cysteine ligase EgtA; Catalyzes the synthesis of gamma-glutamylcysteine (gamma-GC). This compound is used as substrate for the biosynthesis of the low- molecular thiol compound ergothioneine. (427 aa)    
Predicted Functional Partners:
egtB
iron(II)-dependent oxidoreductase EgtB; Catalyzes the oxidative sulfurization of hercynine (N- alpha,N-alpha,N-alpha-trimethyl-L-histidine) into hercynyl-gamma-L- glutamyl-L-cysteine sulfoxide, a step in the biosynthesis pathway of ergothioneine; Belongs to the EgtB family.
 
  
 0.994
egtC
Class II glutamine amidotransferase; Catalyzes the hydrolysis of the gamma-glutamyl amide bond of hercynyl-gamma-L-glutamyl-L-cysteine sulfoxide to produce hercynylcysteine sulfoxide, a step in the biosynthesis pathway of ergothioneine.
 
  
 0.982
egtD
Dimethylhistidine N-methyltransferase; Catalyzes the SAM-dependent triple methylation of the alpha- amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine; Belongs to the methyltransferase superfamily. EgtD family.
 
  
 0.980
ORW66358.1
Ergothioneine biosynthesis PLP-dependent enzyme EgtE; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
  
 0.950
ORW64460.1
Carboxylate--amine ligase; ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity; Belongs to the glutamate--cysteine ligase type 2 family. YbdK subfamily.
    
  0.904
ORW66374.1
Lyase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
  
  0.873
ORW63744.1
Aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.
    
 0.865
ORW67863.1
NAD-glutamate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.
    
  0.854
ORW66353.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
       0.586
ORW66352.1
Organic hydroperoxide resistance protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
       0.559
Your Current Organism:
Mycolicibacter senuensis
NCBI taxonomy Id: 386913
Other names: DSM 44999, JCM 16017, KCTC 19147, M. senuensis, Mycobacterium senuense, Mycobacterium senuense Mun et al. 2008, Mycobacterium sp. 05-832, Mycolicibacter senuensis (Mun et al. 2008) Gupta et al. 2018, strain 05-832
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