| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| NIS_1074 | NIS_1278 | NIS_1074 | NIS_1278 | S-adenosylmethionine synthetase; Probable gene remnant. Similar to the C-terminal region of Aquifex aeolicus VF5 pyrazinamidase/nicotinamidase PncA (198 aa) aq_994; Belongs to the AdoMet synthase family. | O-acetylhomoserine sulfhydrylase. | 0.905 |
| NIS_1074 | NIS_1279 | NIS_1074 | NIS_1279 | S-adenosylmethionine synthetase; Probable gene remnant. Similar to the C-terminal region of Aquifex aeolicus VF5 pyrazinamidase/nicotinamidase PncA (198 aa) aq_994; Belongs to the AdoMet synthase family. | O-acetylhomoserine sulfhydrylase. | 0.905 |
| NIS_1074 | NIS_1309 | NIS_1074 | NIS_1309 | S-adenosylmethionine synthetase; Probable gene remnant. Similar to the C-terminal region of Aquifex aeolicus VF5 pyrazinamidase/nicotinamidase PncA (198 aa) aq_994; Belongs to the AdoMet synthase family. | Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.597 |
| NIS_1074 | glyA | NIS_1074 | NIS_1178 | S-adenosylmethionine synthetase; Probable gene remnant. Similar to the C-terminal region of Aquifex aeolicus VF5 pyrazinamidase/nicotinamidase PncA (198 aa) aq_994; Belongs to the AdoMet synthase family. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.601 |
| NIS_1074 | metE | NIS_1074 | NIS_0886 | S-adenosylmethionine synthetase; Probable gene remnant. Similar to the C-terminal region of Aquifex aeolicus VF5 pyrazinamidase/nicotinamidase PncA (198 aa) aq_994; Belongs to the AdoMet synthase family. | 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. | 0.959 |
| NIS_1074 | metG | NIS_1074 | NIS_0794 | S-adenosylmethionine synthetase; Probable gene remnant. Similar to the C-terminal region of Aquifex aeolicus VF5 pyrazinamidase/nicotinamidase PncA (198 aa) aq_994; Belongs to the AdoMet synthase family. | methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. | 0.541 |
| NIS_1074 | metH | NIS_1074 | NIS_0549 | S-adenosylmethionine synthetase; Probable gene remnant. Similar to the C-terminal region of Aquifex aeolicus VF5 pyrazinamidase/nicotinamidase PncA (198 aa) aq_994; Belongs to the AdoMet synthase family. | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.949 |
| NIS_1074 | metK | NIS_1074 | NIS_0393 | S-adenosylmethionine synthetase; Probable gene remnant. Similar to the C-terminal region of Aquifex aeolicus VF5 pyrazinamidase/nicotinamidase PncA (198 aa) aq_994; Belongs to the AdoMet synthase family. | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.912 |
| NIS_1278 | NIS_1074 | NIS_1278 | NIS_1074 | O-acetylhomoserine sulfhydrylase. | S-adenosylmethionine synthetase; Probable gene remnant. Similar to the C-terminal region of Aquifex aeolicus VF5 pyrazinamidase/nicotinamidase PncA (198 aa) aq_994; Belongs to the AdoMet synthase family. | 0.905 |
| NIS_1278 | NIS_1279 | NIS_1278 | NIS_1279 | O-acetylhomoserine sulfhydrylase. | O-acetylhomoserine sulfhydrylase. | 0.980 |
| NIS_1278 | NIS_1553 | NIS_1278 | NIS_1553 | O-acetylhomoserine sulfhydrylase. | Homoserine dehydrogenase. | 0.841 |
| NIS_1278 | luxS | NIS_1278 | NIS_1601 | O-acetylhomoserine sulfhydrylase. | Autoinducer-2 production protein LuxS; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). Belongs to the LuxS family. | 0.900 |
| NIS_1278 | metE | NIS_1278 | NIS_0886 | O-acetylhomoserine sulfhydrylase. | 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. | 0.918 |
| NIS_1278 | metH | NIS_1278 | NIS_0549 | O-acetylhomoserine sulfhydrylase. | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.950 |
| NIS_1278 | metK | NIS_1278 | NIS_0393 | O-acetylhomoserine sulfhydrylase. | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.905 |
| NIS_1279 | NIS_1074 | NIS_1279 | NIS_1074 | O-acetylhomoserine sulfhydrylase. | S-adenosylmethionine synthetase; Probable gene remnant. Similar to the C-terminal region of Aquifex aeolicus VF5 pyrazinamidase/nicotinamidase PncA (198 aa) aq_994; Belongs to the AdoMet synthase family. | 0.905 |
| NIS_1279 | NIS_1278 | NIS_1279 | NIS_1278 | O-acetylhomoserine sulfhydrylase. | O-acetylhomoserine sulfhydrylase. | 0.980 |
| NIS_1279 | NIS_1553 | NIS_1279 | NIS_1553 | O-acetylhomoserine sulfhydrylase. | Homoserine dehydrogenase. | 0.841 |
| NIS_1279 | luxS | NIS_1279 | NIS_1601 | O-acetylhomoserine sulfhydrylase. | Autoinducer-2 production protein LuxS; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). Belongs to the LuxS family. | 0.900 |
| NIS_1279 | metE | NIS_1279 | NIS_0886 | O-acetylhomoserine sulfhydrylase. | 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. | 0.918 |
