| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| NIS_0815 | NIS_0816 | NIS_0815 | NIS_0816 | Aspartate aminotransferase. | Serine O-acetyltransferase. | 0.826 |
| NIS_0815 | cysK | NIS_0815 | NIS_1469 | Aspartate aminotransferase. | Cysteine synthase A; Belongs to the cysteine synthase/cystathionine beta- synthase family. | 0.905 |
| NIS_0815 | hisS | NIS_0815 | NIS_0818 | Aspartate aminotransferase. | histidyl-tRNA synthetase. | 0.829 |
| NIS_0815 | speA | NIS_0815 | NIS_0817 | Aspartate aminotransferase. | Arginine decarboxylase; Catalyzes the biosynthesis of agmatine from arginine. Belongs to the Orn/Lys/Arg decarboxylase class-II family. SpeA subfamily. | 0.815 |
| NIS_0816 | NIS_0815 | NIS_0816 | NIS_0815 | Serine O-acetyltransferase. | Aspartate aminotransferase. | 0.826 |
| NIS_0816 | NIS_1308 | NIS_0816 | NIS_1308 | Serine O-acetyltransferase. | Phosphoserine phosphatase. | 0.838 |
| NIS_0816 | NIS_1553 | NIS_0816 | NIS_1553 | Serine O-acetyltransferase. | Homoserine dehydrogenase. | 0.847 |
| NIS_0816 | cysK | NIS_0816 | NIS_1469 | Serine O-acetyltransferase. | Cysteine synthase A; Belongs to the cysteine synthase/cystathionine beta- synthase family. | 0.996 |
| NIS_0816 | cysS | NIS_0816 | NIS_1101 | Serine O-acetyltransferase. | cysteinyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. | 0.974 |
| NIS_0816 | glyA | NIS_0816 | NIS_1178 | Serine O-acetyltransferase. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.871 |
| NIS_0816 | hisS | NIS_0816 | NIS_0818 | Serine O-acetyltransferase. | histidyl-tRNA synthetase. | 0.813 |
| NIS_0816 | speA | NIS_0816 | NIS_0817 | Serine O-acetyltransferase. | Arginine decarboxylase; Catalyzes the biosynthesis of agmatine from arginine. Belongs to the Orn/Lys/Arg decarboxylase class-II family. SpeA subfamily. | 0.813 |
| NIS_0816 | tdcB | NIS_0816 | NIS_0808 | Serine O-acetyltransferase. | Threonine dehydratase. | 0.825 |
| NIS_0816 | thrB | NIS_0816 | NIS_0420 | Serine O-acetyltransferase. | Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. | 0.824 |
| NIS_1308 | NIS_0816 | NIS_1308 | NIS_0816 | Phosphoserine phosphatase. | Serine O-acetyltransferase. | 0.838 |
| NIS_1308 | glyA | NIS_1308 | NIS_1178 | Phosphoserine phosphatase. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.948 |
| NIS_1308 | tdcB | NIS_1308 | NIS_0808 | Phosphoserine phosphatase. | Threonine dehydratase. | 0.908 |
| NIS_1553 | NIS_0816 | NIS_1553 | NIS_0816 | Homoserine dehydrogenase. | Serine O-acetyltransferase. | 0.847 |
| NIS_1553 | thrB | NIS_1553 | NIS_0420 | Homoserine dehydrogenase. | Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. | 0.995 |
| cysK | NIS_0815 | NIS_1469 | NIS_0815 | Cysteine synthase A; Belongs to the cysteine synthase/cystathionine beta- synthase family. | Aspartate aminotransferase. | 0.905 |
