| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| NIS_1543 | hisI | NIS_1543 | NIS_1544 | Conserved hypothetical protein. | Histidine biosynthesis bifunctional protein HisI; Bifunctional enzyme, phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphohydrolase; In the N-terminal section; belongs to the PRA-CH family. | 0.724 |
| NIS_1543 | ilvE | NIS_1543 | NIS_1542 | Conserved hypothetical protein. | Branched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. | 0.807 |
| NIS_1553 | hisI | NIS_1553 | NIS_1544 | Homoserine dehydrogenase. | Histidine biosynthesis bifunctional protein HisI; Bifunctional enzyme, phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphohydrolase; In the N-terminal section; belongs to the PRA-CH family. | 0.476 |
| NIS_1553 | ilvE | NIS_1553 | NIS_1542 | Homoserine dehydrogenase. | Branched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. | 0.861 |
| NIS_1553 | thrB | NIS_1553 | NIS_0420 | Homoserine dehydrogenase. | Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. | 0.995 |
| NIS_1602 | NIS_1603 | NIS_1602 | NIS_1603 | Pyruvate:ferredoxin oxidoreductase, beta subunit; Pyruvate synthase component. | Pyruvate:ferredoxin oxidoreductase, alpha subunit; Pyruvate synthase component. | 0.999 |
| NIS_1602 | ilvE | NIS_1602 | NIS_1542 | Pyruvate:ferredoxin oxidoreductase, beta subunit; Pyruvate synthase component. | Branched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. | 0.802 |
| NIS_1602 | leuA | NIS_1602 | NIS_1407 | Pyruvate:ferredoxin oxidoreductase, beta subunit; Pyruvate synthase component. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.906 |
| NIS_1602 | tdcB | NIS_1602 | NIS_0808 | Pyruvate:ferredoxin oxidoreductase, beta subunit; Pyruvate synthase component. | Threonine dehydratase. | 0.808 |
| NIS_1603 | NIS_1602 | NIS_1603 | NIS_1602 | Pyruvate:ferredoxin oxidoreductase, alpha subunit; Pyruvate synthase component. | Pyruvate:ferredoxin oxidoreductase, beta subunit; Pyruvate synthase component. | 0.999 |
| NIS_1603 | ilvE | NIS_1603 | NIS_1542 | Pyruvate:ferredoxin oxidoreductase, alpha subunit; Pyruvate synthase component. | Branched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. | 0.804 |
| NIS_1603 | leuA | NIS_1603 | NIS_1407 | Pyruvate:ferredoxin oxidoreductase, alpha subunit; Pyruvate synthase component. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.907 |
| NIS_1603 | tdcB | NIS_1603 | NIS_0808 | Pyruvate:ferredoxin oxidoreductase, alpha subunit; Pyruvate synthase component. | Threonine dehydratase. | 0.807 |
| hisI | NIS_1543 | NIS_1544 | NIS_1543 | Histidine biosynthesis bifunctional protein HisI; Bifunctional enzyme, phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphohydrolase; In the N-terminal section; belongs to the PRA-CH family. | Conserved hypothetical protein. | 0.724 |
| hisI | NIS_1553 | NIS_1544 | NIS_1553 | Histidine biosynthesis bifunctional protein HisI; Bifunctional enzyme, phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphohydrolase; In the N-terminal section; belongs to the PRA-CH family. | Homoserine dehydrogenase. | 0.476 |
| hisI | ilvD | NIS_1544 | NIS_0126 | Histidine biosynthesis bifunctional protein HisI; Bifunctional enzyme, phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphohydrolase; In the N-terminal section; belongs to the PRA-CH family. | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. | 0.659 |
| hisI | ilvE | NIS_1544 | NIS_1542 | Histidine biosynthesis bifunctional protein HisI; Bifunctional enzyme, phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphohydrolase; In the N-terminal section; belongs to the PRA-CH family. | Branched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. | 0.868 |
| hisI | leuA | NIS_1544 | NIS_1407 | Histidine biosynthesis bifunctional protein HisI; Bifunctional enzyme, phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphohydrolase; In the N-terminal section; belongs to the PRA-CH family. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.595 |
| hisI | tdcB | NIS_1544 | NIS_0808 | Histidine biosynthesis bifunctional protein HisI; Bifunctional enzyme, phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphohydrolase; In the N-terminal section; belongs to the PRA-CH family. | Threonine dehydratase. | 0.437 |
| ilvD | hisI | NIS_0126 | NIS_1544 | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. | Histidine biosynthesis bifunctional protein HisI; Bifunctional enzyme, phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphohydrolase; In the N-terminal section; belongs to the PRA-CH family. | 0.659 |
