node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SUN_0205 | SUN_1968 | SUN_0205 | SUN_1968 | Riboflavin synthase, alpha subunit. | Riboflavin biosynthesis protein RibG; Bifunctional enzyme, diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase. | 0.997 |
SUN_0205 | ribA | SUN_0205 | SUN_2088 | Riboflavin synthase, alpha subunit. | GTP cyclohydrolase II; Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate; Belongs to the GTP cyclohydrolase II family. | 0.992 |
SUN_0205 | ribB | SUN_0205 | SUN_1141 | Riboflavin synthase, alpha subunit. | Riboflavin biosynthesis bifunctional protein RibBA; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family. | 0.999 |
SUN_0205 | ribE | SUN_0205 | SUN_1919 | Riboflavin synthase, alpha subunit. | Riboflavin synthase, beta chain; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. | 0.997 |
SUN_0205 | ribF | SUN_0205 | SUN_0463 | Riboflavin synthase, alpha subunit. | Riboflavin biosynthesis regulatory protein RibF. | 0.934 |
SUN_1968 | SUN_0205 | SUN_1968 | SUN_0205 | Riboflavin biosynthesis protein RibG; Bifunctional enzyme, diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase. | Riboflavin synthase, alpha subunit. | 0.997 |
SUN_1968 | SUN_1972 | SUN_1968 | SUN_1972 | Riboflavin biosynthesis protein RibG; Bifunctional enzyme, diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase. | Conserved hypothetical protein. | 0.651 |
SUN_1968 | hisG | SUN_1968 | SUN_0424 | Riboflavin biosynthesis protein RibG; Bifunctional enzyme, diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. | 0.661 |
SUN_1968 | nadD | SUN_1968 | SUN_2205 | Riboflavin biosynthesis protein RibG; Bifunctional enzyme, diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase. | Nicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | 0.730 |
SUN_1968 | ribA | SUN_1968 | SUN_2088 | Riboflavin biosynthesis protein RibG; Bifunctional enzyme, diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase. | GTP cyclohydrolase II; Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate; Belongs to the GTP cyclohydrolase II family. | 0.997 |
SUN_1968 | ribB | SUN_1968 | SUN_1141 | Riboflavin biosynthesis protein RibG; Bifunctional enzyme, diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase. | Riboflavin biosynthesis bifunctional protein RibBA; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; Belongs to the DHBP synthase family. | 0.999 |
SUN_1968 | ribE | SUN_1968 | SUN_1919 | Riboflavin biosynthesis protein RibG; Bifunctional enzyme, diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase. | Riboflavin synthase, beta chain; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. | 0.991 |
SUN_1968 | ribF | SUN_1968 | SUN_0463 | Riboflavin biosynthesis protein RibG; Bifunctional enzyme, diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase. | Riboflavin biosynthesis regulatory protein RibF. | 0.724 |
SUN_1968 | ubiE | SUN_1968 | SUN_1967 | Riboflavin biosynthesis protein RibG; Bifunctional enzyme, diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase. | Ubiquinone/menaquinone biosynthesis methyltransferase; Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3- methyl-6-methoxy-1,4-benzoquinol (DMQH2). | 0.850 |
SUN_1968 | xseA | SUN_1968 | SUN_1966 | Riboflavin biosynthesis protein RibG; Bifunctional enzyme, diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase. | Exodeoxyribonuclease VII, large subunit; Bidirectionally degrades single-stranded DNA into large acid- insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides; Belongs to the XseA family. | 0.649 |
SUN_1972 | SUN_1968 | SUN_1972 | SUN_1968 | Conserved hypothetical protein. | Riboflavin biosynthesis protein RibG; Bifunctional enzyme, diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase. | 0.651 |
SUN_1972 | ubiE | SUN_1972 | SUN_1967 | Conserved hypothetical protein. | Ubiquinone/menaquinone biosynthesis methyltransferase; Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3- methyl-6-methoxy-1,4-benzoquinol (DMQH2). | 0.468 |
SUN_1972 | xseA | SUN_1972 | SUN_1966 | Conserved hypothetical protein. | Exodeoxyribonuclease VII, large subunit; Bidirectionally degrades single-stranded DNA into large acid- insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides; Belongs to the XseA family. | 0.414 |
hisG | SUN_1968 | SUN_0424 | SUN_1968 | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. | Riboflavin biosynthesis protein RibG; Bifunctional enzyme, diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase. | 0.661 |
nadD | SUN_1968 | SUN_2205 | SUN_1968 | Nicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | Riboflavin biosynthesis protein RibG; Bifunctional enzyme, diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase. | 0.730 |