node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SUN_2140 | gltB | SUN_2140 | SUN_0907 | Acetolactate synthase, large subunit; Belongs to the TPP enzyme family. | Glutamate synthase (NADPH), large chain. | 0.571 |
SUN_2140 | ilvC | SUN_2140 | SUN_0443 | Acetolactate synthase, large subunit; Belongs to the TPP enzyme family. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.990 |
SUN_2140 | ilvD | SUN_2140 | SUN_2427 | Acetolactate synthase, large subunit; Belongs to the TPP enzyme family. | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. | 0.929 |
SUN_2140 | ilvE | SUN_2140 | SUN_0239 | Acetolactate synthase, large subunit; Belongs to the TPP enzyme family. | Branched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. | 0.561 |
SUN_2140 | ilvH | SUN_2140 | SUN_1822 | Acetolactate synthase, large subunit; Belongs to the TPP enzyme family. | Acetolactate synthase, small subunit. | 0.998 |
SUN_2140 | ilvI | SUN_2140 | SUN_1823 | Acetolactate synthase, large subunit; Belongs to the TPP enzyme family. | Acetolactate synthase, large subunit. | 0.922 |
SUN_2140 | leuA | SUN_2140 | SUN_1956 | Acetolactate synthase, large subunit; Belongs to the TPP enzyme family. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.911 |
SUN_2140 | leuB | SUN_2140 | SUN_1705 | Acetolactate synthase, large subunit; Belongs to the TPP enzyme family. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. | 0.957 |
SUN_2140 | leuC | SUN_2140 | SUN_0147 | Acetolactate synthase, large subunit; Belongs to the TPP enzyme family. | 3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.593 |
gltB | SUN_2140 | SUN_0907 | SUN_2140 | Glutamate synthase (NADPH), large chain. | Acetolactate synthase, large subunit; Belongs to the TPP enzyme family. | 0.571 |
gltB | ilvC | SUN_0907 | SUN_0443 | Glutamate synthase (NADPH), large chain. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.772 |
gltB | ilvD | SUN_0907 | SUN_2427 | Glutamate synthase (NADPH), large chain. | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. | 0.875 |
gltB | ilvE | SUN_0907 | SUN_0239 | Glutamate synthase (NADPH), large chain. | Branched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. | 0.456 |
gltB | ilvH | SUN_0907 | SUN_1822 | Glutamate synthase (NADPH), large chain. | Acetolactate synthase, small subunit. | 0.596 |
gltB | ilvI | SUN_0907 | SUN_1823 | Glutamate synthase (NADPH), large chain. | Acetolactate synthase, large subunit. | 0.571 |
gltB | leuA | SUN_0907 | SUN_1956 | Glutamate synthase (NADPH), large chain. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.480 |
gltB | leuB | SUN_0907 | SUN_1705 | Glutamate synthase (NADPH), large chain. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. | 0.624 |
gltB | leuC | SUN_0907 | SUN_0147 | Glutamate synthase (NADPH), large chain. | 3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.655 |
ilvC | SUN_2140 | SUN_0443 | SUN_2140 | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | Acetolactate synthase, large subunit; Belongs to the TPP enzyme family. | 0.990 |
ilvC | gltB | SUN_0443 | SUN_0907 | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | Glutamate synthase (NADPH), large chain. | 0.772 |