node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
LVIS_0040 | LVIS_0576 | LVIS_0040 | LVIS_0576 | 5'-nucleotidase/2',3'-cyclic phosphodiesterase related esterase; Belongs to the 5'-nucleotidase family. | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | 0.900 |
LVIS_0040 | LVIS_1396 | LVIS_0040 | LVIS_1396 | 5'-nucleotidase/2',3'-cyclic phosphodiesterase related esterase; Belongs to the 5'-nucleotidase family. | Deoxycytidylate deaminase. | 0.904 |
LVIS_0040 | tdk | LVIS_0040 | LVIS_1291 | 5'-nucleotidase/2',3'-cyclic phosphodiesterase related esterase; Belongs to the 5'-nucleotidase family. | Thymidine kinase. | 0.904 |
LVIS_0040 | thyA | LVIS_0040 | LVIS_0784 | 5'-nucleotidase/2',3'-cyclic phosphodiesterase related esterase; Belongs to the 5'-nucleotidase family. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.904 |
LVIS_0040 | tmk | LVIS_0040 | LVIS_0604 | 5'-nucleotidase/2',3'-cyclic phosphodiesterase related esterase; Belongs to the 5'-nucleotidase family. | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.910 |
LVIS_0576 | LVIS_0040 | LVIS_0576 | LVIS_0040 | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | 5'-nucleotidase/2',3'-cyclic phosphodiesterase related esterase; Belongs to the 5'-nucleotidase family. | 0.900 |
LVIS_0576 | LVIS_1396 | LVIS_0576 | LVIS_1396 | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | Deoxycytidylate deaminase. | 0.943 |
LVIS_0576 | tdk | LVIS_0576 | LVIS_1291 | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | Thymidine kinase. | 0.958 |
LVIS_0576 | thyA | LVIS_0576 | LVIS_0784 | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.958 |
LVIS_0576 | tmk | LVIS_0576 | LVIS_0604 | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.942 |
LVIS_0785 | LVIS_1252 | LVIS_0785 | LVIS_1252 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Folylpolyglutamate synthase; Belongs to the folylpolyglutamate synthase family. | 0.932 |
LVIS_0785 | glyA | LVIS_0785 | LVIS_1287 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.988 |
LVIS_0785 | thyA | LVIS_0785 | LVIS_0784 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.998 |
LVIS_1252 | LVIS_0785 | LVIS_1252 | LVIS_0785 | Folylpolyglutamate synthase; Belongs to the folylpolyglutamate synthase family. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.932 |
LVIS_1252 | folD | LVIS_1252 | LVIS_0978 | Folylpolyglutamate synthase; Belongs to the folylpolyglutamate synthase family. | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.549 |
LVIS_1252 | glyA | LVIS_1252 | LVIS_1287 | Folylpolyglutamate synthase; Belongs to the folylpolyglutamate synthase family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.697 |
LVIS_1252 | thyA | LVIS_1252 | LVIS_0784 | Folylpolyglutamate synthase; Belongs to the folylpolyglutamate synthase family. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.855 |
LVIS_1396 | LVIS_0040 | LVIS_1396 | LVIS_0040 | Deoxycytidylate deaminase. | 5'-nucleotidase/2',3'-cyclic phosphodiesterase related esterase; Belongs to the 5'-nucleotidase family. | 0.904 |
LVIS_1396 | LVIS_0576 | LVIS_1396 | LVIS_0576 | Deoxycytidylate deaminase. | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | 0.943 |
LVIS_1396 | tdk | LVIS_1396 | LVIS_1291 | Deoxycytidylate deaminase. | Thymidine kinase. | 0.928 |