STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AGK60516.1PF00206:TIGR00928:COG0015; PFAM: Lyase; COG: Adenylosuccinate lyase; TIGR: adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (448 aa)    
Predicted Functional Partners:
purC
Phosphoribosylaminoimidazole-succinocarboxamide synthase; PF01259:TIGR00081:COG0152; PFAM: SAICARsynthetase; COG: Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase; TIGR: phosphoribosylaminoimidazole-succinocarboxamide synthase.
  
 0.999
purA
Adenylosuccinate synthase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.
 
 0.999
purF
Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.
 
 
 0.997
purD
Phosphoribosylamine--glycine ligase; PF01071:TIGR00877:COG0151; PFAM: Phosphoribosylglycinamidesynthetase,ATP-grasp(A)domain; COG: Phosphoribosylamine-glycine ligase; TIGR: phosphoribosylamine--glycine ligase; Belongs to the GARS family.
  
 
 0.995
purL
Phosphoribosylformylglycinamidine synthase subunit II; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to [...]
 
  
 0.994
AGK62116.1
Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).
  
  
 0.994
AGK60788.1
Hypothetical protein; PF02142:COG0138; PFAM: MGS-likedomain; COG: AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful).
  
 
 0.991
purM
Phosphoribosylformylglycinamidine cyclo-ligase; PF02769:TIGR00878:COG0150; PFAM: AIRsynthaserelatedprotein,C-terminaldomain; COG: Phosphoribosylaminoimidazole (AIR) synthetase; TIGR: phosphoribosylaminoimidazole synthetase.
  
 
 0.987
AGK60371.1
PF06973:COG1759; PFAM: Domainofunknownfunction(DUF1297); COG: ATP-utilizing enzymes of ATP-grasp superfamily (probably carboligases).
 
  
 0.968
purS
Phosphoribosylformylglycinamidine synthase, purS protein; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought [...]
 
 
 0.964
Your Current Organism:
Archaeoglobus sulfaticallidus
NCBI taxonomy Id: 387631
Other names: A. sulfaticallidus PM70-1, Archaeoglobus sp. PM70-1, Archaeoglobus sulfaticallidus PM70-1
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.