STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
mptEUncharacterized Rossmann fold enzyme; Catalyzes the transfer of diphosphate from ATP to 6- hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6-hydroxymethyl- 7,8-dihydropterin diphosphate (6-HMDP); Belongs to the archaeal 6-HMPDK family. (207 aa)    
Predicted Functional Partners:
mptD
Uncharacterized protein conserved in archaea; Catalyzes the conversion of 7,8-dihydroneopterin (H2Neo) to 6-hydroxymethyl-7,8-dihydropterin (6-HMD); Belongs to the archaeal dihydroneopterin aldolase family.
 
  
 0.966
AGK60212.1
PF00753:COG1237; PFAM: Metallo-beta-lactamasesuperfamily; COG: Metal-dependent hydrolases of the beta-lactamase superfamily II.
    
  0.902
ileS
Isoleucyl-tRNA synthetase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.
       0.875
AGK60823.1
Hypothetical protein; PF03706:TIGR00374:COG0392; PFAM: Uncharacterisedproteinfamily(UPF0104); COG: Predicted integral membrane protein; TIGR: conserved hypothetical protein.
 
     0.806
AGK60824.1
Hypothetical protein; PF13641:COG1215; PFAM: Glycosyltransferaselikefamily2; COG: Glycosyltransferases, probably involved in cell wall biogenesis.
       0.794
AGK60825.1
Glycosyltransferase; PF00534:COG0438; PFAM: Glycosyltransferasesgroup1; COG: Glycosyltransferase.
       0.777
mptA
GTP cyclohydrolase MptA; Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin.
 
   
 0.674
AGK60568.1
Putative membrane protein; PF04123:COG2237; PFAM: Domainofunknownfunction(DUF373); COG: Predicted membrane protein.
 
     0.637
AGK61429.1
Hypothetical protein.
  
     0.622
priS
DNA primase, eukaryotic-type, small subunit, putative; Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extens [...]
  
     0.616
Your Current Organism:
Archaeoglobus sulfaticallidus
NCBI taxonomy Id: 387631
Other names: A. sulfaticallidus PM70-1, Archaeoglobus sp. PM70-1, Archaeoglobus sulfaticallidus PM70-1
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.