node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
APEX1 | APEX2 | ENSGAGP00000020347 | ENSGAGP00000015270 | DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. | Apurinic/apyrimidinic endodeoxyribonuclease 2. | 0.837 |
APEX1 | ENSGAGP00000015412 | ENSGAGP00000020347 | ENSGAGP00000015412 | DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. | Uncharacterized protein. | 0.700 |
APEX1 | LIG1 | ENSGAGP00000020347 | ENSGAGP00000000912 | DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. | DNA ligase. | 0.930 |
APEX1 | MGMT | ENSGAGP00000020347 | ENSGAGP00000001358 | DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. | O-6-methylguanine-DNA methyltransferase. | 0.432 |
APEX1 | MPG | ENSGAGP00000020347 | ENSGAGP00000006536 | DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. | N-methylpurine DNA glycosylase. | 0.794 |
APEX1 | NTHL1 | ENSGAGP00000020347 | ENSGAGP00000029628 | DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. | Endonuclease III-like protein 1; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines; Belongs to the Nth/MutY family. | 0.994 |
APEX1 | UNG | ENSGAGP00000020347 | ENSGAGP00000034078 | DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. | Uracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine. | 0.886 |
APEX2 | APEX1 | ENSGAGP00000015270 | ENSGAGP00000020347 | Apurinic/apyrimidinic endodeoxyribonuclease 2. | DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. | 0.837 |
APEX2 | ENSGAGP00000015412 | ENSGAGP00000015270 | ENSGAGP00000015412 | Apurinic/apyrimidinic endodeoxyribonuclease 2. | Uncharacterized protein. | 0.518 |
APEX2 | LIG1 | ENSGAGP00000015270 | ENSGAGP00000000912 | Apurinic/apyrimidinic endodeoxyribonuclease 2. | DNA ligase. | 0.853 |
APEX2 | MGMT | ENSGAGP00000015270 | ENSGAGP00000001358 | Apurinic/apyrimidinic endodeoxyribonuclease 2. | O-6-methylguanine-DNA methyltransferase. | 0.432 |
APEX2 | MPG | ENSGAGP00000015270 | ENSGAGP00000006536 | Apurinic/apyrimidinic endodeoxyribonuclease 2. | N-methylpurine DNA glycosylase. | 0.794 |
APEX2 | NTHL1 | ENSGAGP00000015270 | ENSGAGP00000029628 | Apurinic/apyrimidinic endodeoxyribonuclease 2. | Endonuclease III-like protein 1; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines; Belongs to the Nth/MutY family. | 0.942 |
APEX2 | UNG | ENSGAGP00000015270 | ENSGAGP00000034078 | Apurinic/apyrimidinic endodeoxyribonuclease 2. | Uracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine. | 0.882 |
CLIP4 | MPG | ENSGAGP00000031580 | ENSGAGP00000006536 | CAP-Gly domain containing linker protein family member 4. | N-methylpurine DNA glycosylase. | 0.558 |
ELP1 | MPG | ENSGAGP00000027112 | ENSGAGP00000006536 | Elongator complex protein 1. | N-methylpurine DNA glycosylase. | 0.631 |
ENSGAGP00000015412 | APEX1 | ENSGAGP00000015412 | ENSGAGP00000020347 | Uncharacterized protein. | DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. | 0.700 |
ENSGAGP00000015412 | APEX2 | ENSGAGP00000015412 | ENSGAGP00000015270 | Uncharacterized protein. | Apurinic/apyrimidinic endodeoxyribonuclease 2. | 0.518 |
ENSGAGP00000015412 | LIG1 | ENSGAGP00000015412 | ENSGAGP00000000912 | Uncharacterized protein. | DNA ligase. | 0.943 |
ENSGAGP00000015412 | MPG | ENSGAGP00000015412 | ENSGAGP00000006536 | Uncharacterized protein. | N-methylpurine DNA glycosylase. | 0.639 |