node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
COQ10A | COQ2 | ENSGAGP00000010003 | ENSGAGP00000020545 | Coenzyme Q10A. | 4-hydroxybenzoate polyprenyltransferase, mitochondrial; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate. | 0.553 |
COQ10A | COQ3 | ENSGAGP00000010003 | ENSGAGP00000034956 | Coenzyme Q10A. | Ubiquinone biosynthesis O-methyltransferase, mitochondrial; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family. | 0.565 |
COQ10A | COQ6 | ENSGAGP00000010003 | ENSGAGP00000013264 | Coenzyme Q10A. | Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial; FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl- 4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6. | 0.569 |
COQ10A | ETHE1 | ENSGAGP00000010003 | ENSGAGP00000015414 | Coenzyme Q10A. | ETHE1 persulfide dioxygenase. | 0.513 |
COQ10A | HAGH | ENSGAGP00000010003 | ENSGAGP00000005165 | Coenzyme Q10A. | Hydroxyacylglutathione hydrolase. | 0.513 |
COQ10A | HAGHL | ENSGAGP00000010003 | ENSGAGP00000005161 | Coenzyme Q10A. | Hydroxyacylglutathione hydrolase like. | 0.513 |
COQ10A | LACTB2 | ENSGAGP00000010003 | ENSGAGP00000012977 | Coenzyme Q10A. | Lactamase beta 2. | 0.527 |
COQ10A | NDUFAB1 | ENSGAGP00000010003 | ENSGAGP00000008211 | Coenzyme Q10A. | Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis. | 0.661 |
COQ10A | OXSM | ENSGAGP00000010003 | ENSGAGP00000018204 | Coenzyme Q10A. | 3-oxoacyl-[acyl-carrier-protein] synthase; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. | 0.795 |
COQ10A | PALB2 | ENSGAGP00000010003 | ENSGAGP00000003122 | Coenzyme Q10A. | Partner and localizer of BRCA2. | 0.661 |
COQ2 | COQ10A | ENSGAGP00000020545 | ENSGAGP00000010003 | 4-hydroxybenzoate polyprenyltransferase, mitochondrial; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate. | Coenzyme Q10A. | 0.553 |
COQ2 | COQ3 | ENSGAGP00000020545 | ENSGAGP00000034956 | 4-hydroxybenzoate polyprenyltransferase, mitochondrial; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate. | Ubiquinone biosynthesis O-methyltransferase, mitochondrial; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family. | 0.949 |
COQ2 | COQ6 | ENSGAGP00000020545 | ENSGAGP00000013264 | 4-hydroxybenzoate polyprenyltransferase, mitochondrial; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate. | Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial; FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl- 4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6. | 0.937 |
COQ3 | COQ10A | ENSGAGP00000034956 | ENSGAGP00000010003 | Ubiquinone biosynthesis O-methyltransferase, mitochondrial; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family. | Coenzyme Q10A. | 0.565 |
COQ3 | COQ2 | ENSGAGP00000034956 | ENSGAGP00000020545 | Ubiquinone biosynthesis O-methyltransferase, mitochondrial; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family. | 4-hydroxybenzoate polyprenyltransferase, mitochondrial; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate. | 0.949 |
COQ3 | COQ6 | ENSGAGP00000034956 | ENSGAGP00000013264 | Ubiquinone biosynthesis O-methyltransferase, mitochondrial; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family. | Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial; FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl- 4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6. | 0.984 |
COQ3 | NDUFAB1 | ENSGAGP00000034956 | ENSGAGP00000008211 | Ubiquinone biosynthesis O-methyltransferase, mitochondrial; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family. | Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis. | 0.531 |
COQ3 | OXSM | ENSGAGP00000034956 | ENSGAGP00000018204 | Ubiquinone biosynthesis O-methyltransferase, mitochondrial; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family. | 3-oxoacyl-[acyl-carrier-protein] synthase; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. | 0.883 |
COQ3 | PALB2 | ENSGAGP00000034956 | ENSGAGP00000003122 | Ubiquinone biosynthesis O-methyltransferase, mitochondrial; O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway; Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family. | Partner and localizer of BRCA2. | 0.531 |
COQ6 | COQ10A | ENSGAGP00000013264 | ENSGAGP00000010003 | Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial; FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl- 4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6. | Coenzyme Q10A. | 0.569 |