STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ENSGAGP00000010963AP-2 complex subunit alpha; Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold bu [...] (1015 aa)    
Predicted Functional Partners:
AP2S1
AP complex subunit sigma; Belongs to the adaptor complexes small subunit family.
    
 0.998
ENSGAGP00000010605
EH domain-containing protein.
    
  0.991
ITSN2
Intersectin 2.
    
  0.991
AP2B1
AP complex subunit beta.
   
0.987
AP1B1
AP complex subunit beta.
   
0.986
ENSGAGP00000034509
Uncharacterized protein.
    
 0.981
AP4B1
AP complex subunit beta; Belongs to the adaptor complexes large subunit family.
   
 0.980
ITSN1
Intersectin 1.
    
 0.954
NECAP1
NECAP endocytosis associated 1.
    
  0.931
EPS15L1
Epidermal growth factor receptor pathway substrate 15 like 1.
    
 0.926
Your Current Organism:
Gopherus agassizii
NCBI taxonomy Id: 38772
Other names: G. agassizii, Gopherus agassizi, Gopherus polyphemus agassizii, USNM 7888, desert tortoise
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.