STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ENSGAGP00000021506Uncharacterized protein. (633 aa)    
Predicted Functional Partners:
AGO2
Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include ago2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]
    
 0.598
ENSGAGP00000019974
Ubiquitin-like domain-containing protein.
    
  0.598
ICOS
Inducible T cell costimulator.
    
  0.545
UBA52
Ubiquitin A-52 residue ribosomal protein fusion product 1.
    
  0.516
GAS7
Growth arrest specific 7.
    
  0.497
ENSGAGP00000028873
Ubiquitin-like domain-containing protein.
    
  0.495
ENSGAGP00000017897
UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.
    
  0.493
UBE2L5
Ubiquitin conjugating enzyme E2 L5; Belongs to the ubiquitin-conjugating enzyme family.
    
  0.493
ENSGAGP00000023227
Pyrin domain-containing protein.
    
  0.489
ZFAND4
Zinc finger AN1-type containing 4.
    
  0.488
Your Current Organism:
Gopherus agassizii
NCBI taxonomy Id: 38772
Other names: G. agassizii, Gopherus agassizi, Gopherus polyphemus agassizii, USNM 7888, desert tortoise
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