EAZ80450.2 protein (Algoriphagus machipongonensis)

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second shell of interactors

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a 3D structure is known or predicted

Edges:

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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[Homology]

Score

EAZ80450.2

Putative outer membrane protein, probably involved in nutrient binding. (1017 aa)

Predicted Functional Partners:

EAZ80451.1

0.949

EAZ82478.1

0.856

EAZ82622.1

0.764

EAZ80452.1

0.743

EAZ80428.1

0.740

EAZ80617.1

0.730

EAZ82662.1

0.707

EAZ81856.1

0.704

EAZ80453.1

0.704

EAZ80454.1

0.696

Your Current Organism:

Algoriphagus machipongonensis

NCBI taxonomy Id: 388413
Other names: A. machipongonensis, ATCC BAA-2233, Algoriphagus machipongonensis Alegado et al. 2013, Algoriphagus sp. PR1, DSM 24695, strain PR1

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EAZ80428.1	EAZ80450.2	ALPR1_05880	ALPR1_05990	Hypothetical protein.	Putative outer membrane protein, probably involved in nutrient binding.	0.740
EAZ80428.1	EAZ80451.1	ALPR1_05880	ALPR1_05995	Hypothetical protein.	Putative outer membrane protein probably involved in nutrient binding.	0.671
EAZ80428.1	EAZ80452.1	ALPR1_05880	ALPR1_06000	Hypothetical protein.	Heme-binding domain-containing protein.	0.754
EAZ80428.1	EAZ80453.1	ALPR1_05880	ALPR1_06005	Hypothetical protein.	Probable secreted glycosyl hydrolase.	0.740
EAZ80428.1	EAZ80454.1	ALPR1_05880	ALPR1_06010	Hypothetical protein.	Hypothetical protein.	0.611
EAZ80428.1	EAZ82662.1	ALPR1_05880	ALPR1_10615	Hypothetical protein.	TonB-dependent receptor.	0.432
EAZ80450.2	EAZ80428.1	ALPR1_05990	ALPR1_05880	Putative outer membrane protein, probably involved in nutrient binding.	Hypothetical protein.	0.740
EAZ80450.2	EAZ80451.1	ALPR1_05990	ALPR1_05995	Putative outer membrane protein, probably involved in nutrient binding.	Putative outer membrane protein probably involved in nutrient binding.	0.949
EAZ80450.2	EAZ80452.1	ALPR1_05990	ALPR1_06000	Putative outer membrane protein, probably involved in nutrient binding.	Heme-binding domain-containing protein.	0.743
EAZ80450.2	EAZ80453.1	ALPR1_05990	ALPR1_06005	Putative outer membrane protein, probably involved in nutrient binding.	Probable secreted glycosyl hydrolase.	0.704
EAZ80450.2	EAZ80454.1	ALPR1_05990	ALPR1_06010	Putative outer membrane protein, probably involved in nutrient binding.	Hypothetical protein.	0.696
EAZ80450.2	EAZ80617.1	ALPR1_05990	ALPR1_06825	Putative outer membrane protein, probably involved in nutrient binding.	Putative outer membrane protein probably involved in nutrient binding.	0.730
EAZ80450.2	EAZ81856.1	ALPR1_05990	ALPR1_01405	Putative outer membrane protein, probably involved in nutrient binding.	Putative outer membrane protein probably involved in nutrient binding.	0.704
EAZ80450.2	EAZ82478.1	ALPR1_05990	ALPR1_09695	Putative outer membrane protein, probably involved in nutrient binding.	Putative outer membrane protein probably involved in nutrient binding.	0.856
EAZ80450.2	EAZ82622.1	ALPR1_05990	ALPR1_10415	Putative outer membrane protein, probably involved in nutrient binding.	Putative outer membrane protein, probably involved in nutrient binding.	0.764
EAZ80450.2	EAZ82662.1	ALPR1_05990	ALPR1_10615	Putative outer membrane protein, probably involved in nutrient binding.	TonB-dependent receptor.	0.707
EAZ80451.1	EAZ80428.1	ALPR1_05995	ALPR1_05880	Putative outer membrane protein probably involved in nutrient binding.	Hypothetical protein.	0.671
EAZ80451.1	EAZ80450.2	ALPR1_05995	ALPR1_05990	Putative outer membrane protein probably involved in nutrient binding.	Putative outer membrane protein, probably involved in nutrient binding.	0.949
EAZ80451.1	EAZ80452.1	ALPR1_05995	ALPR1_06000	Putative outer membrane protein probably involved in nutrient binding.	Heme-binding domain-containing protein.	0.767
EAZ80451.1	EAZ80453.1	ALPR1_05995	ALPR1_06005	Putative outer membrane protein probably involved in nutrient binding.	Probable secreted glycosyl hydrolase.	0.777

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

42

average node degree:

7.64

avg. local clustering coefficient:

0.917

expected number of edges:

14

PPI enrichment p-value:

2.05e-09

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0019344

Cysteine biosynthetic process

5 of 7

2.29

3.85

1.62e-08

GO:1901607

Alpha-amino acid biosynthetic process

11 of 81

1.57

3.51

1.12e-14

GO:0009097

Isoleucine biosynthetic process

4 of 7

2.2

2.9

1.46e-06

GO:0009069

Serine family amino acid metabolic process

6 of 29

1.76

2.86

5.38e-08

GO:0009099

Valine biosynthetic process

3 of 4

2.32

2.25

4.84e-05

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004795

Threonine synthase activity

3 of 3

2.44

2.06

0.00014

GO:0016835

Carbon-oxygen lyase activity

5 of 41

1.53

1.63

8.00e-05

GO:0016829

Lyase activity

7 of 104

1.27

1.47

1.22e-05

GO:0030170

Pyridoxal phosphate binding

4 of 30

1.57

1.43

0.00048

GO:0052656

L-isoleucine transaminase activity

2 of 2

2.44

1.24

0.0052

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005737

Cytoplasm

10 of 876

0.5

0.38

0.0038

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1781

Sulfur amino acid biosynthetic process, and Threonine metabolic process

6 of 21

1.9

3.27

1.80e-08

CL:1719

Cellular amino acid biosynthetic process

8 of 52

1.63

3.0

6.62e-10

CL:1811

Threonine synthase activity, and Threonine biosynthetic process

3 of 5

2.22

1.89

0.00023

CL:1500

Biosynthesis of amino acids, and Carbon metabolism

11 of 187

1.21

1.87

4.02e-11

CL:1549

Valine, leucine and isoleucine biosynthesis

3 of 12

1.84

1.38

0.0016

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map01230

Biosynthesis of amino acids

11 of 130

1.37

2.55

1.57e-13

map00260

Glycine, serine and threonine metabolism

6 of 46

1.56

2.29

2.93e-07

map00750

Vitamin B6 metabolism

3 of 10

1.92

1.84

0.00016

map00290

Valine, leucine and isoleucine biosynthesis

4 of 27

1.61

1.73

7.59e-05

map00270

Cysteine and methionine metabolism

4 of 36

1.49

1.51

0.00016

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0663

Pyridoxal phosphate

3 of 17

1.69

1.2

0.0030

KW-0028

Amino-acid biosynthesis

4 of 45

1.39

1.07

0.0027

KW-0822

Tryptophan biosynthesis

2 of 6

1.96

0.99

0.0126

KW-0456

Lyase

4 of 59

1.27

0.98

0.0030

KW-0032

Aminotransferase

2 of 16

1.54

0.67

0.0448

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00291

Pyridoxal-phosphate dependent enzyme

5 of 11

2.1

3.06

3.88e-07

PF01063

Amino-transferase class IV

2 of 2

2.44

0.99

0.0151

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR036052

Tryptophan synthase beta chain-like, PALP domain superfamily

5 of 11

2.1

2.89

1.01e-06

IPR001926

Tryptophan synthase beta chain-like, PALP domain

5 of 11

2.1

2.89

1.01e-06

IPR000634

Serine/threonine dehydratase, pyridoxal-phosphate-binding site

3 of 3

2.44

1.92

0.00026

IPR043132

Branched-chain-amino-acid aminotransferase-like, C-terminal

2 of 2

2.44

0.93

0.0197

IPR043131

Branched-chain-amino-acid aminotransferase-like, N-terminal

2 of 2

2.44

0.93

0.0197

(more ...)

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