EAZ79807.1 protein (Algoriphagus machipongonensis)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

EAZ79807.1

Hypothetical protein. (463 aa)

Predicted Functional Partners:

EAZ79809.1

0.946

EAZ79810.1

0.944

EAZ79808.1

0.943

EAZ79812.1

0.920

EAZ79816.2

0.839

EAZ79800.2

0.793

EAZ79811.1

0.784

EAZ79805.2

0.776

EAZ79801.1

0.764

EAZ79806.1

0.756

Your Current Organism:

Algoriphagus machipongonensis

NCBI taxonomy Id: 388413
Other names: A. machipongonensis, ATCC BAA-2233, Algoriphagus machipongonensis Alegado et al. 2013, Algoriphagus sp. PR1, DSM 24695, strain PR1

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EAZ79800.2	EAZ79801.1	ALPR1_09248	ALPR1_09253	Putative polysaccharide export protein, BexD/CtrA/VexA family.	Putative tyrosine-protein kinase.	0.997
EAZ79800.2	EAZ79805.2	ALPR1_09248	ALPR1_09273	Putative polysaccharide export protein, BexD/CtrA/VexA family.	Glycosyl transferase.	0.656
EAZ79800.2	EAZ79806.1	ALPR1_09248	ALPR1_09278	Putative polysaccharide export protein, BexD/CtrA/VexA family.	Asparagine synthase (glutamine-hydrolyzing).	0.638
EAZ79800.2	EAZ79807.1	ALPR1_09248	ALPR1_09283	Putative polysaccharide export protein, BexD/CtrA/VexA family.	Hypothetical protein.	0.793
EAZ79800.2	EAZ79808.1	ALPR1_09248	ALPR1_09288	Putative polysaccharide export protein, BexD/CtrA/VexA family.	Glycosyl transferase; Overlaps another CDS with the same product name.	0.720
EAZ79800.2	EAZ79809.1	ALPR1_09248	ALPR1_09293	Putative polysaccharide export protein, BexD/CtrA/VexA family.	Glycosyl transferase; Overlaps another CDS with the same product name.	0.795
EAZ79800.2	EAZ79810.1	ALPR1_09248	ALPR1_09298	Putative polysaccharide export protein, BexD/CtrA/VexA family.	Glycosyl transferase; Overlaps another CDS with the same product name.	0.734
EAZ79800.2	EAZ79811.1	ALPR1_09248	ALPR1_09303	Putative polysaccharide export protein, BexD/CtrA/VexA family.	Putative transmembrane acyltransferase.	0.699
EAZ79800.2	EAZ79812.1	ALPR1_09248	ALPR1_09308	Putative polysaccharide export protein, BexD/CtrA/VexA family.	Hypothetical protein.	0.786
EAZ79800.2	EAZ79816.2	ALPR1_09248	ALPR1_09328	Putative polysaccharide export protein, BexD/CtrA/VexA family.	Hypothetical protein.	0.641
EAZ79801.1	EAZ79800.2	ALPR1_09253	ALPR1_09248	Putative tyrosine-protein kinase.	Putative polysaccharide export protein, BexD/CtrA/VexA family.	0.997
EAZ79801.1	EAZ79805.2	ALPR1_09253	ALPR1_09273	Putative tyrosine-protein kinase.	Glycosyl transferase.	0.686
EAZ79801.1	EAZ79806.1	ALPR1_09253	ALPR1_09278	Putative tyrosine-protein kinase.	Asparagine synthase (glutamine-hydrolyzing).	0.675
EAZ79801.1	EAZ79807.1	ALPR1_09253	ALPR1_09283	Putative tyrosine-protein kinase.	Hypothetical protein.	0.764
EAZ79801.1	EAZ79808.1	ALPR1_09253	ALPR1_09288	Putative tyrosine-protein kinase.	Glycosyl transferase; Overlaps another CDS with the same product name.	0.756
EAZ79801.1	EAZ79809.1	ALPR1_09253	ALPR1_09293	Putative tyrosine-protein kinase.	Glycosyl transferase; Overlaps another CDS with the same product name.	0.792
EAZ79801.1	EAZ79810.1	ALPR1_09253	ALPR1_09298	Putative tyrosine-protein kinase.	Glycosyl transferase; Overlaps another CDS with the same product name.	0.837
EAZ79801.1	EAZ79811.1	ALPR1_09253	ALPR1_09303	Putative tyrosine-protein kinase.	Putative transmembrane acyltransferase.	0.764
EAZ79801.1	EAZ79812.1	ALPR1_09253	ALPR1_09308	Putative tyrosine-protein kinase.	Hypothetical protein.	0.745
EAZ79801.1	EAZ79816.2	ALPR1_09253	ALPR1_09328	Putative tyrosine-protein kinase.	Hypothetical protein.	0.851

page 1 of 6

Network Stats

number of nodes:

11

number of edges:

31

average node degree:

5.64

avg. local clustering coefficient:

0.726

expected number of edges:

14

PPI enrichment p-value:

3.63e-05

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005996

Monosaccharide metabolic process

6 of 90

1.75

2.41

1.66e-06

GO:0009089

Lysine biosynthetic process via diaminopimelate

2 of 2

2.93

1.2

0.0068

GO:0009090

Homoserine biosynthetic process

2 of 3

2.75

1.17

0.0076

GO:0046365

Monosaccharide catabolic process

3 of 40

1.8

1.07

0.0076

GO:0009088

Threonine biosynthetic process

2 of 5

2.53

1.05

0.0119

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004073

Aspartate-semialdehyde dehydrogenase activity

2 of 2

2.93

1.06

0.0120

GO:0051287

NAD binding

3 of 50

1.7

0.83

0.0221

GO:0003824

Catalytic activity

11 of 3980

0.37

0.26

0.0487

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:4997

Mixed, incl. Pentose catabolic process, and Triokinase activity

4 of 37

1.96

1.84

0.00018

CL:4999

D-xylose metabolic process, and Triokinase activity

3 of 19

2.12

1.46

0.0016

CL:11556

Galactose catabolism

2 of 5

2.53

1.12

0.0090

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00040

Pentose and glucuronate interconversions

3 of 76

1.52

0.98

0.0074

map00261

Monobactam biosynthesis

2 of 35

1.68

0.7

0.0433

map00300

Lysine biosynthesis

2 of 46

1.56

0.67

0.0459

map00052

Galactose metabolism

2 of 42

1.6

0.67

0.0459

map01100

Metabolic pathways

10 of 2776

0.48

0.36

0.0074

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-70370

Galactose catabolism

2 of 6

2.45

0.81

0.0332

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF02774

Semialdehyde dehydrogenase, dimerisation domain

2 of 2

2.93

1.17

0.0076

PF01408

Oxidoreductase family, NAD-binding Rossmann fold

2 of 11

2.19

0.71

0.0493

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR012280

Semialdehyde dehydrogenase, dimerisation domain

2 of 2

2.93

0.92

0.0219

IPR012080

Aspartate-semialdehyde dehydrogenase

2 of 2

2.93

0.92

0.0219

IPR005676

Aspartate-semialdehyde dehydrogenase, peptidoglycan lacking

2 of 2

2.93

0.92

0.0219

IPR000534

Semialdehyde dehydrogenase, NAD-binding

2 of 3

2.75

0.92

0.0219

IPR000683

Gfo/Idh/MocA-like oxidoreductase, N-terminal

2 of 11

2.19

0.72

0.0472

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00859

Semialdehyde dehydrogenase, NAD binding domain

2 of 3

2.75

1.31

0.0041

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