STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
EAZ80122.1Putative helicase. (753 aa)    
Predicted Functional Partners:
EAZ81347.1
DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]
  
 
 0.823
EAZ79585.1
Putative UvrD/REP helicase domain protein; Belongs to the helicase family. UvrD subfamily.
  
 
 0.806
truB
tRNA pseudouridine synthase B; Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs; Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
   
 
  0.641
EAZ80313.1
ATP-dependent DNA helicase RecQ.
   
 
 0.561
EAZ79604.1
ATP-dependent DNA helicase RecQ.
   
 
 0.561
EAZ80123.1
Putative protease synthase and sporulation negative regulatory protein.
       0.546
topA
DNA topoisomerase; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA superc [...]
   
 
 0.535
EAZ83051.2
Hypothetical protein.
  
 
 0.526
EAZ81218.1
Putative RecF/RecN/SMC N domain protein.
   
 
 0.526
EAZ81318.1
ATP-dependent DNA helicase PcrA.
  
 
 0.526
Your Current Organism:
Algoriphagus machipongonensis
NCBI taxonomy Id: 388413
Other names: A. machipongonensis, ATCC BAA-2233, Algoriphagus machipongonensis Alegado et al. 2013, Algoriphagus sp. PR1, DSM 24695, strain PR1
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.