STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
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Co-occurrence
Co-expression
Experiments
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[Homology]
Score
dnaNDNA polymerase III, beta chain, putative; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initi [...] (378 aa)    
Predicted Functional Partners:
holB
DNA polymerase III, delta' subunit, putative; GC: 44.89%; Codon Adaptation Index (CAI): 0.795; Protein involved in 3'-5' exonuclease activity.
 
 0.997
dnaA
Chromosomal replication initiator protein dnaA, putative; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. Belongs to the DnaA family.
 
 
 0.996
polA
DNA polymerase I - 3'-5' exonuclease and polymerase domains, putative; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.
 
 0.996
dnaX
DNA-directed DNA polymerase III chain, putative; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.
 
 
 0.995
holA
Conserved hypothetical protein; GC: 41.93%; Codon Adaptation Index (CAI): 0.805. Helix-turn-helix prediction: AraC. Curator(s): X. Ge; Protein involved in DNA replication.
  
 
 0.993
dnaE
DNA-polymerase III alpha-chain, putative; GC: 46.17%; Codon Adaptation Index (CAI): 0.784. Curator(s): L. Ozaki; Protein involved in 3'-5' exonuclease activity and nucleotidyltransferase activity.
  
 
 0.992
mutL
DNA mismatch repair protein, putative; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.
   
 0.975
pcrA
ATP-dependent DNA helicase, putative; GC: 48.01%; Codon Adaptation Index (CAI): 0.775. Curator(s): L. Ozaki; Protein involved in DNA repair.
 
 
 0.958
polC
DNA polymerase III polC-type, putative; Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity.
    
 0.952
dinG
ATP-dependent DNA helicase; 3'-5' exonuclease.
  
 
 0.943
Your Current Organism:
Streptococcus sanguinis SK36
NCBI taxonomy Id: 388919
Other names: S. sanguinis SK36, Streptococcus sanguinis str. SK36, Streptococcus sanguinis strain SK36
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