STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Co-expression
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[Homology]
Score
purNPhosphoribosylglycinamide (GAR) formyltransferase, putative; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (187 aa)    
Predicted Functional Partners:
purL
Phosphoribosylformylglycinamidine synthase, putative; GC: 48.7%; Codon Adaptation Index (CAI): 0.782. Curator(s): J. Alves; Protein involved in catalytic activity and ligase activity.
  
 
 0.999
purM
Phosphoribosylformylglycinamidine cyclo-ligase, putative; GC: 47.31%; Codon Adaptation Index (CAI): 0.795. Curator(s): J. Alves.
  
 0.999
purH
Bifunctional purine biosynthesis protein purH, putative; GC: 49.65%; Codon Adaptation Index (CAI): 0.779. Curator(s): J. Alves.
 0.999
purD
Phosphoribosylamine-glycine ligase; GC: 51.7%; Codon Adaptation Index (CAI): 0.748. Curator(s): J. Alves; Protein involved in ligase activity; Belongs to the GARS family.
 
 0.999
purF
Glutamine phosphoribosylpyrophosphate amidotransferase, putative; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.
 
 
 0.998
purK
Phosphoribosylaminoimidazole carboxylase, ATPase subunit, putative; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).
 
 
 0.996
purC
Phosphoribosylaminoimidazole-succinocarboxamide synthase, putative; GC: 41.95%; Codon Adaptation Index (CAI): 0.786. Curator(s): J. Alves; Protein involved in purine nucleotide biosynthesis; Belongs to the SAICAR synthetase family.
 
 
 0.993
purE
Phosphoribosylaminoimidazole carboxylase, catalytic subunit, putative; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).
 
  
 0.992
folD
Methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase, putative; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate.
 
 
 0.975
glyA
Serine hydroxymethyltransferase, putative; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
 0.963
Your Current Organism:
Streptococcus sanguinis SK36
NCBI taxonomy Id: 388919
Other names: S. sanguinis SK36, Streptococcus sanguinis str. SK36, Streptococcus sanguinis strain SK36
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