Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
co-expression
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gene co-occurrence
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[Homology]
Score
purHBifunctional purine biosynthesis protein purH, putative; GC: 49.65%; Codon Adaptation Index (CAI): 0.779. Curator(s): J. Alves. (520 aa)    
Predicted Functional Partners:
purF
Glutamine phosphoribosylpyrophosphate amidotransferase, putative; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.
 
 
 0.999
purM
Phosphoribosylformylglycinamidine cyclo-ligase, putative; GC: 47.31%; Codon Adaptation Index (CAI): 0.795. Curator(s): J. Alves.
 
  
 0.999
purN
Phosphoribosylglycinamide (GAR) formyltransferase, putative; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.
 0.999
purB
Adenylosuccinate lyase, putative; GC: 51.85%; Codon Adaptation Index (CAI): 0.749. Curator(s): J. Alves; Protein involved in lyase activity; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
  
 0.998
guaB
Inosine-5'-monophosphate dehydrogenase, putative; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
  
 0.998
purC
Phosphoribosylaminoimidazole-succinocarboxamide synthase, putative; GC: 41.95%; Codon Adaptation Index (CAI): 0.786. Curator(s): J. Alves; Protein involved in purine nucleotide biosynthesis; Belongs to the SAICAR synthetase family.
 
 
 0.996
purD
Phosphoribosylamine-glycine ligase; GC: 51.7%; Codon Adaptation Index (CAI): 0.748. Curator(s): J. Alves; Protein involved in ligase activity; Belongs to the GARS family.
 
 
 0.996
purL
Phosphoribosylformylglycinamidine synthase, putative; GC: 48.7%; Codon Adaptation Index (CAI): 0.782. Curator(s): J. Alves; Protein involved in catalytic activity and ligase activity.
  
  
 0.994
purE
Phosphoribosylaminoimidazole carboxylase, catalytic subunit, putative; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).
 
  
 0.993
purA
Adenylosuccinate synthetase, putative; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.
  
 0.991
Your Current Organism:
Streptococcus sanguinis SK36
NCBI taxonomy Id: 388919
Other names: S. sanguinis SK36, Streptococcus sanguinis str. SK36, Streptococcus sanguinis strain SK36
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