Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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tgtQueuine tRNA-ribosyltransferase, putative; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose [...] (380 aa)    
Predicted Functional Partners:
queA
S-adenosylmethio nine:tRNA-ribosyltransferase-isomerase (queuine synthetase), putative; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).
 
 
 0.984
SSA_0105
Uridine kinase, putative; GC: 47.26%; Codon Adaptation Index (CAI): 0.723. Curator(s): M. Serrano; Protein involved in transferase activity.
  
    0.820
SSA_0103
Integral membrane protein, putative; GC: 42.28%; Transmembrane domains: 6. Codon Adaptation Index (CAI): 0.727. SignalP prediction: Yes (prob. 0.47); Curator(s): M. Serrano.
       0.723
miaA
tRNA delta(2)-isopentenylpyrophosphate transferase, putative; Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A); Belongs to the IPP transferase family.
  
  
 0.666
yajC
Preprotein translocase subunit YajC, putative; GC: 45.24%; Transmembrane domains: 1. Codon Adaptation Index (CAI): 0.814. LipoP prediction: SpI. Curator(s): J. Alves.
  
  
 0.651
ccl
Citrulline cluster-linked gene, putative; GC: 37.98%; Transmembrane domains: 5. Codon Adaptation Index (CAI): 0.808.
  
     0.594
trmD
tRNA (Guanine-N(1)-)-methyltransferase, putative; Specifically methylates guanosine-37 in various tRNAs. Belongs to the RNA methyltransferase TrmD family.
  
  
 0.578
sunL
RRNA methyltransferase RsmB, putative; Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA.
  
  
 0.569
truB
tRNA pseudouridine synthase B, putative; Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs; Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.
  
  
 0.552
trmB
tRNA (guanine-N(7)-)-methyltransferase, putative; Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
  
  
 0.548
Your Current Organism:
Streptococcus sanguinis SK36
NCBI taxonomy Id: 388919
Other names: S. sanguinis SK36, Streptococcus sanguinis str. SK36, Streptococcus sanguinis strain SK36
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