Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
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gene co-occurrence
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folPDihydropteroate synthase, putative; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. (317 aa)    
Predicted Functional Partners:
SSA_0198
Dihydrofolate synthetase, putative; GC: 48.24%; Codon Adaptation Index (CAI): 0.749. Curator(s): M. Serrano; Belongs to the folylpolyglutamate synthase family.
 
 0.999
folE
GTP cyclohydrolase I, putative; GC: 49.37%; Codon Adaptation Index (CAI): 0.761. Helix-turn-helix prediction: AraC. Curator(s): M. Serrano; Protein involved in hydrolase activity.
  
 0.999
folK
Bifunctional folate synthesis protein, putative; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin.
 
 0.999
SSA_2237
Dihydrofolate:folylpolyglutamate synthetase, putative; GC: 48.66%; Codon Adaptation Index (CAI): 0.763; Belongs to the folylpolyglutamate synthase family.
 
 0.995
pabB
Anthranilate/para-aminobenzoate synthases component I/ Chorismate binding enzyme, putative; GC: 49.3%; Codon Adaptation Index (CAI): 0.761. Curator(s): M. Chaplin, J. Alves.
 
 
 0.980
thyA
Thymidylate synthase, putative; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
   
  
 0.734
SSA_1783
Xanthosine triphosphate pyrophosphatase (NTPase/HAM1 family), putative; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family.
  
  
 0.714
birA
Biotin--[acetyl-CoA-carboxylase] ligase, putative; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family.
     
 0.696
aroE
Shikimate dehydrogenase, putative; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
  
  
 0.679
trpG
Anthranilate synthase component II, putative; GC: 45.21%; Codon Adaptation Index (CAI): 0.783. Curator(s): P. Xu; Protein involved in folic acid biosynthesis.
 
  
 0.672
Your Current Organism:
Streptococcus sanguinis SK36
NCBI taxonomy Id: 388919
Other names: S. sanguinis SK36, Streptococcus sanguinis str. SK36, Streptococcus sanguinis strain SK36
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