Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
folEGTP cyclohydrolase I, putative; GC: 49.37%; Codon Adaptation Index (CAI): 0.761. Helix-turn-helix prediction: AraC. Curator(s): M. Serrano; Protein involved in hydrolase activity. (184 aa)    
Predicted Functional Partners:
folP
Dihydropteroate synthase, putative; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives.
  
 0.999
folK
Bifunctional folate synthesis protein, putative; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin.
  
 0.999
SSA_0198
Dihydrofolate synthetase, putative; GC: 48.24%; Codon Adaptation Index (CAI): 0.749. Curator(s): M. Serrano; Belongs to the folylpolyglutamate synthase family.
  
  
 0.932
SSA_0854
Conserved hypothetical protein; GC: 43.11%; Codon Adaptation Index (CAI): 0.733. Curator(s): L. Ozaki; Protein involved in hydrolase activity and ligase activity; Belongs to the Nudix hydrolase family.
  
 
  0.902
relA
GTP pyrophosphokinase, putative; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.
     
  0.800
SSA_1210
GTP pyrophosphokinase, putative; GC: 43.45%; Codon Adaptation Index (CAI): 0.805; Protein involved in kinase activity and guanosine tetraphosphate metabolism.
     
  0.800
SSA_1795
Guanosine 3',5'-bis-pyrophosphate (ppGpp) synthetase, putative; GC: 46.38%; Codon Adaptation Index (CAI): 0.768. Curator(s): J. Alves; Protein involved in guanosine tetraphosphate metabolism.
     
  0.800
nrdD
Ribonucleotide reductase, class III, anaerobic, putative; GC: 48.63%; Codon Adaptation Index (CAI): 0.764; Protein involved in ribonucleoside-triphosphate reductase activity and metabolism.
     
  0.800
SSA_1783
Xanthosine triphosphate pyrophosphatase (NTPase/HAM1 family), putative; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family.
  
  
 0.719
SSA_2237
Dihydrofolate:folylpolyglutamate synthetase, putative; GC: 48.66%; Codon Adaptation Index (CAI): 0.763; Belongs to the folylpolyglutamate synthase family.
  
  
 0.716
Your Current Organism:
Streptococcus sanguinis SK36
NCBI taxonomy Id: 388919
Other names: S. sanguinis SK36, Streptococcus sanguinis str. SK36, Streptococcus sanguinis strain SK36
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