STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Co-occurrence
Co-expression
Experiments
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[Homology]
Score
folKBifunctional folate synthesis protein, putative; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. (270 aa)    
Predicted Functional Partners:
folP
Dihydropteroate synthase, putative; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives.
 
 0.999
folE
GTP cyclohydrolase I, putative; GC: 49.37%; Codon Adaptation Index (CAI): 0.761. Helix-turn-helix prediction: AraC. Curator(s): M. Serrano; Protein involved in hydrolase activity.
  
 0.999
pabB
Anthranilate/para-aminobenzoate synthases component I/ Chorismate binding enzyme, putative; GC: 49.3%; Codon Adaptation Index (CAI): 0.761. Curator(s): M. Chaplin, J. Alves.
 
  
 0.945
SSA_0198
Dihydrofolate synthetase, putative; GC: 48.24%; Codon Adaptation Index (CAI): 0.749. Curator(s): M. Serrano; Belongs to the folylpolyglutamate synthase family.
 
  
 0.932
SSA_1783
Xanthosine triphosphate pyrophosphatase (NTPase/HAM1 family), putative; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family.
  
  
 0.924
SSA_2237
Dihydrofolate:folylpolyglutamate synthetase, putative; GC: 48.66%; Codon Adaptation Index (CAI): 0.763; Belongs to the folylpolyglutamate synthase family.
  
 0.861
birA
Biotin--[acetyl-CoA-carboxylase] ligase, putative; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family.
  
  
 0.860
murB
UDP-N-acetylenolpyruvoylglucosamine reductase, putative; Cell wall formation.
  
  
 0.831
hisS
Histidyl-tRNA synthetase, putative; GC: 47.23%; Codon Adaptation Index (CAI): 0.785; Protein involved in histidyl-tRNA aminoacylation.
     
 0.822
potC
ABC transporter membrane-spanning permease-spermidine/putrescine transport, putative; GC: 42.64%; Transporter classification TC:3.A.1.11.1. Transmembrane domains: 7. Codon Adaptation Index (CAI): 0.787. SignalP prediction: Yes (prob. 0.529); Helix-turn-helix prediction: AraC.
     
 0.803
Your Current Organism:
Streptococcus sanguinis SK36
NCBI taxonomy Id: 388919
Other names: S. sanguinis SK36, Streptococcus sanguinis str. SK36, Streptococcus sanguinis strain SK36
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