| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| birA | clpP | SSA_0999 | SSA_1731 | Biotin--[acetyl-CoA-carboxylase] ligase, putative; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family. | ATP-dependent Clp protease, proteolytic subunit, putative; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.483 |
| birA | dnaK | SSA_0999 | SSA_2007 | Biotin--[acetyl-CoA-carboxylase] ligase, putative; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family. | Chaperone protein dnaK/HSP70, putative; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.466 |
| birA | groS | SSA_0999 | SSA_0225 | Biotin--[acetyl-CoA-carboxylase] ligase, putative; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family. | 10 kDa chaperonin; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.743 |
| birA | hrcA | SSA_0999 | SSA_2009 | Biotin--[acetyl-CoA-carboxylase] ligase, putative; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family. | Heat shock transcription repressor HrcA, putative; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | 0.642 |
| clpC | clpP | SSA_2199 | SSA_1731 | ATP-dependent Clp protease, ATP-binding subunit, putative; GC: 50.16%; Codon Adaptation Index (CAI): 0.776; Protein involved in protein metabolism; Belongs to the ClpA/ClpB family. | ATP-dependent Clp protease, proteolytic subunit, putative; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.974 |
| clpC | ctsR | SSA_2199 | SSA_2200 | ATP-dependent Clp protease, ATP-binding subunit, putative; GC: 50.16%; Codon Adaptation Index (CAI): 0.776; Protein involved in protein metabolism; Belongs to the ClpA/ClpB family. | Firmicutes transcriptional repressor of class III stress genes (CtsR), putative; GC: 44.73%; Codon Adaptation Index (CAI): 0.768. Curator(s): J. Alves; Protein involved in response to unfolded protein; Belongs to the CtsR family. | 0.952 |
| clpC | dnaJ | SSA_2199 | SSA_2005 | ATP-dependent Clp protease, ATP-binding subunit, putative; GC: 50.16%; Codon Adaptation Index (CAI): 0.776; Protein involved in protein metabolism; Belongs to the ClpA/ClpB family. | Chaperone protein dnaJ, putative; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions betwe [...] | 0.713 |
| clpC | dnaK | SSA_2199 | SSA_2007 | ATP-dependent Clp protease, ATP-binding subunit, putative; GC: 50.16%; Codon Adaptation Index (CAI): 0.776; Protein involved in protein metabolism; Belongs to the ClpA/ClpB family. | Chaperone protein dnaK/HSP70, putative; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.853 |
| clpC | groEL | SSA_2199 | SSA_0226 | ATP-dependent Clp protease, ATP-binding subunit, putative; GC: 50.16%; Codon Adaptation Index (CAI): 0.776; Protein involved in protein metabolism; Belongs to the ClpA/ClpB family. | 60 kDa chaperonin; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.679 |
| clpC | groS | SSA_2199 | SSA_0225 | ATP-dependent Clp protease, ATP-binding subunit, putative; GC: 50.16%; Codon Adaptation Index (CAI): 0.776; Protein involved in protein metabolism; Belongs to the ClpA/ClpB family. | 10 kDa chaperonin; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.737 |
| clpC | grpE | SSA_2199 | SSA_2008 | ATP-dependent Clp protease, ATP-binding subunit, putative; GC: 50.16%; Codon Adaptation Index (CAI): 0.776; Protein involved in protein metabolism; Belongs to the ClpA/ClpB family. | Molecular chaperone GrpE (HSP-70 cofactor), putative; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction [...] | 0.610 |
| clpP | birA | SSA_1731 | SSA_0999 | ATP-dependent Clp protease, proteolytic subunit, putative; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | Biotin--[acetyl-CoA-carboxylase] ligase, putative; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family. | 0.483 |
| clpP | clpC | SSA_1731 | SSA_2199 | ATP-dependent Clp protease, proteolytic subunit, putative; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | ATP-dependent Clp protease, ATP-binding subunit, putative; GC: 50.16%; Codon Adaptation Index (CAI): 0.776; Protein involved in protein metabolism; Belongs to the ClpA/ClpB family. | 0.974 |
| clpP | ctsR | SSA_1731 | SSA_2200 | ATP-dependent Clp protease, proteolytic subunit, putative; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | Firmicutes transcriptional repressor of class III stress genes (CtsR), putative; GC: 44.73%; Codon Adaptation Index (CAI): 0.768. Curator(s): J. Alves; Protein involved in response to unfolded protein; Belongs to the CtsR family. | 0.698 |
| clpP | dnaJ | SSA_1731 | SSA_2005 | ATP-dependent Clp protease, proteolytic subunit, putative; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | Chaperone protein dnaJ, putative; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions betwe [...] | 0.658 |
| clpP | dnaK | SSA_1731 | SSA_2007 | ATP-dependent Clp protease, proteolytic subunit, putative; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | Chaperone protein dnaK/HSP70, putative; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.723 |
| clpP | groEL | SSA_1731 | SSA_0226 | ATP-dependent Clp protease, proteolytic subunit, putative; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 60 kDa chaperonin; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.850 |
| clpP | groS | SSA_1731 | SSA_0225 | ATP-dependent Clp protease, proteolytic subunit, putative; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 10 kDa chaperonin; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.833 |
| clpP | grpE | SSA_1731 | SSA_2008 | ATP-dependent Clp protease, proteolytic subunit, putative; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | Molecular chaperone GrpE (HSP-70 cofactor), putative; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction [...] | 0.736 |
| clpP | hrcA | SSA_1731 | SSA_2009 | ATP-dependent Clp protease, proteolytic subunit, putative; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | Heat shock transcription repressor HrcA, putative; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | 0.578 |
