STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
tpxThiol peroxidase, putative; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides; Belongs to the peroxiredoxin family. Tpx subfamily. (176 aa)    
Predicted Functional Partners:
sodA
Mn/Fe-dependent superoxide dismutase, putative; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family.
  
  
 0.883
ssaB
Manganese/Zinc ABC transporter substrate-binding lipoprotein precursor, putative; GC: 42.37%; Transporter classification TC:3.A.1.15.2. Codon Adaptation Index (CAI): 0.786. LipoP prediction: SpII. SignalP prediction: Yes (prob. 1); Curator(s): P. Manque, J. Alves; Belongs to the bacterial solute-binding protein 9 family.
     
 0.802
ssaA
ABC-type Mn/Zn transporter, ATP-ase component, putative; GC: 45.47%; Transporter classification TC:3.A.1.15.2. Codon Adaptation Index (CAI): 0.783. Curator(s): P. Manque, J. Alves; Protein involved in nucleoside-triphosphatase activity.
     
 0.761
gor
Glutathione reductase, putative; GC: 45.01%; Codon Adaptation Index (CAI): 0.79; Protein involved in FAD binding.
   
  
 0.750
nox
H2O-forming NADH dehydrogenase, putative; GC: 40.38%; Codon Adaptation Index (CAI): 0.812. Curator(s): J. Alves.
      
 0.738
codY
GTP-sensing transcriptional pleiotropic repressor, putative; DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor; Belongs to the CodY family.
      
 0.646
SSA_0256
Metalloregulator ScaR (Fe/Mn-dependent transcriptional repressor), putative; GC: 46.6%; Codon Adaptation Index (CAI): 0.768. Curator(s): P. Manque, J. Alves; Protein involved in regulation of transcription, DNA-dependent.
  
  
 0.641
recJ
Single-stranded DNA-specific exonuclease, 5'-3', putative; GC: 46.24%; Codon Adaptation Index (CAI): 0.791. Helix-turn-helix prediction: AraC; Protein involved in 5'-3' exonuclease activity.
     
 0.621
SSA_1865
Thioredoxin reductase, putative; GC: 48.63%; Codon Adaptation Index (CAI): 0.781; Protein involved in removal of superoxide radicals.
  
  
 0.608
pepO
Zinc metalloproteinase in scaA 5'region, putative; GC: 48.44%; Codon Adaptation Index (CAI): 0.785. Curator(s): P. Manque; Protein involved in metal ion binding and hydrolase activity.
       0.569
Your Current Organism:
Streptococcus sanguinis SK36
NCBI taxonomy Id: 388919
Other names: S. sanguinis SK36, Streptococcus sanguinis str. SK36, Streptococcus sanguinis strain SK36
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.