STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
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gcpSecreted metalloendopeptidase Gcp; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction; Belongs to the KAE1 / TsaD family. (336 aa)    
Predicted Functional Partners:
SSA_0316
Conserved hypothetical protein; GC: 50.95%; Codon Adaptation Index (CAI): 0.767. Curator(s): T. Kitten; Protein involved in O-sialoglycoprotein endopeptidase activity.
 
 
 0.993
SSA_1911
Conserved uncharacterized protein; GC: 46.71%; Codon Adaptation Index (CAI): 0.777.
 
 
 0.934
rimI
Ribosomal protein alanine acetyl transferase, putative; Acetylates the N-terminal alanine of ribosomal protein S18.
  
  
 0.879
SSA_0319
Branched-chain amino acid permease (L-methionine, L-isoleucine, leucine and valine), putative; GC: 46.7%; Transporter classification TC:2.A.78.1.2. Transmembrane domains: 6. Codon Adaptation Index (CAI): 0.761. Curator(s): T. Kitten.
       0.849
SSA_0320
Membrane protein, putative; GC: 41.89%; Transmembrane domains: 3. Codon Adaptation Index (CAI): 0.768. SignalP prediction: Yes (prob. 0.536); Curator(s): T. Kitten.
       0.849
SSA_0315
Transcriptional regulator, MarR family, putative; GC: 46.45%; Codon Adaptation Index (CAI): 0.774. Curator(s): T. Kitten; Protein involved in regulation of transcription, DNA-dependent.
       0.844
pheT
Phenylalanyl-tRNA synthetase beta chain, putative; GC: 47.55%; Codon Adaptation Index (CAI): 0.791. Curator(s): T. Kitten; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.
 
   
 0.699
dnaN
DNA polymerase III, beta chain, putative; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initi [...]
 
   
 0.603
topA
DNA topoisomerase I, putative; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removin [...]
 
   
 0.603
ksgA
Dimethyladenosine transferase, putative; Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.
 
  
 0.598
Your Current Organism:
Streptococcus sanguinis SK36
NCBI taxonomy Id: 388919
Other names: S. sanguinis SK36, Streptococcus sanguinis str. SK36, Streptococcus sanguinis strain SK36
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