Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
SSA_0433Methenyl tetrahydrofolate cyclohydrolase, putative; GC: 49.12%; Codon Adaptation Index (CAI): 0.792. Curator(s): M. Chaplin. (208 aa)    
Predicted Functional Partners:
SSA_0434
Glutamate formiminotransferase, putative; GC: 47.11%; Codon Adaptation Index (CAI): 0.796. Curator(s): M. Chaplin.
 
  0.999
fhs1
Formate--tetrahydrofolate ligase, putative; GC: 48.06%; Codon Adaptation Index (CAI): 0.797. Curator(s): M. Chaplin; Protein involved in ligase activity and folic acid and derivative biosynthesis.
    
 0.980
folD
Methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase, putative; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate.
    
 0.943
fhs
Formate--tetrahydrofolate ligase, putative; GC: 45.3%; Codon Adaptation Index (CAI): 0.806; Protein involved in ligase activity and folic acid and derivative biosynthesis; Belongs to the formate--tetrahydrofolate ligase family.
    
 0.917
SSA_2171
Conserved hypothetical protein; GC: 44.88%; Codon Adaptation Index (CAI): 0.783; Protein involved in 5-formyltetrahydrofolate cyclo-ligase activity and metabolism; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.
    
  0.916
purH
Bifunctional purine biosynthesis protein purH, putative; GC: 49.65%; Codon Adaptation Index (CAI): 0.779. Curator(s): J. Alves.
    
  0.902
purN
Phosphoribosylglycinamide (GAR) formyltransferase, putative; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.
     
  0.900
SSA_0431
Conserved hypothetical protein; GC: 47%; Codon Adaptation Index (CAI): 0.712. Curator(s): M. Chaplin.
 
     0.826
hutH
Histidine ammonia-lyase, putative; GC: 48.1%; Codon Adaptation Index (CAI): 0.784. Curator(s): M. Chaplin; Protein involved in lyase activity; Belongs to the PAL/histidase family.
  
  
 0.796
hutU
Urocanate hydratase, putative; Catalyzes the conversion of urocanate to 4-imidazolone-5- propionate.
 
     0.692
Your Current Organism:
Streptococcus sanguinis SK36
NCBI taxonomy Id: 388919
Other names: S. sanguinis SK36, Streptococcus sanguinis str. SK36, Streptococcus sanguinis strain SK36
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