Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
cobDCobalamin biosynthesis protein cobD, putative; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. (316 aa)    
Predicted Functional Partners:
cobQ-2
Cobyric acid synthase, putative; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily.
 
 
 0.988
cobU
Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase, putative; GC: 53.5%; Codon Adaptation Index (CAI): 0.765. Curator(s): M. Chaplin, J. Alves; Protein involved in nucleotidyltransferase activity.
 
 
 0.987
cbiA
Cobyrinic acid A,C-diamide synthase, putative; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family.
  
 0.983
CbiC
Precorrin-8X methylmutase / precorrin isomerase, putative; GC: 45.64%; Codon Adaptation Index (CAI): 0.768. Curator(s): M. Chaplin, J. Alves; Protein involved in intramolecular transferase activity, transferring acyl groups and precorrin-8X methylmutase activity.
 
  
 0.954
CbiC-2
Precorrin-8X methylmutase / precorrin isomerase, putative; GC: 46.38%; Codon Adaptation Index (CAI): 0.781. Curator(s): M. Chaplin, J. Alves; Protein involved in intramolecular transferase activity, transferring acyl groups and precorrin-8X methylmutase activity.
 
  
 0.954
SSA_0482
ATP:cobalamin adenosyl transferase, putative; GC: 50.87%; Codon Adaptation Index (CAI): 0.746. Curator(s): M. Chaplin; Protein involved in transferase activity; Belongs to the Cob(I)alamin adenosyltransferase family.
    
 0.929
cbiD
Cobalt-precorrin-6A synthase [deacetylating], putative; Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A.
 
  
 0.926
cobL
Precorrin-6B methylase 2,putative; GC: 51.23%; Codon Adaptation Index (CAI): 0.757. Curator(s): M. Chaplin, J. Alves; Protein involved in transferase activity and S-adenosylmethionine-dependent methyltransferase activity.
 
   
 0.922
cobM
Precorrin-4 methylase, putative; GC: 49.61%; Codon Adaptation Index (CAI): 0.787. Curator(s): M. Chaplin, J. Alves; Protein involved in precorrin-4 C11-methyltransferase activity.
 
  
 0.922
SSA_0471
CbiG protein, putative; GC: 50.91%; Codon Adaptation Index (CAI): 0.751. Curator(s): M. Chaplin; Protein involved in transferase activity and cobalamin biosynthesis.
 
  
 0.917
Your Current Organism:
Streptococcus sanguinis SK36
NCBI taxonomy Id: 388919
Other names: S. sanguinis SK36, Streptococcus sanguinis str. SK36, Streptococcus sanguinis strain SK36
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