Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Co-expression
Experiments
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[Homology]
Score
SSA_0474Uroporphyrin-III C-methyltransferase/uroporphyrinogen-III synthase, putative; GC: 50.07%; Codon Adaptation Index (CAI): 0.77. Curator(s): M. Chaplin; Protein involved in transferase activity. (479 aa)    
Predicted Functional Partners:
hemC
Porphobilinogen deaminase, putative; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family.
 0.999
SSA_0483
Siroheme synthase, putative; GC: 50.46%; Codon Adaptation Index (CAI): 0.724. Curator(s): M. Chaplin; Protein involved in NAD binding.
 
 
 0.997
SSA_0487
Delta-aminolevulinic acid dehydratase, putative; GC: 50.82%; Codon Adaptation Index (CAI): 0.781. Curator(s): M. Chaplin; Protein involved in lyase activity; Belongs to the ALAD family.
 
 
 0.994
SSA_0476
Precorrin-2 C20-methyltransferase, putative; GC: 49.29%; Codon Adaptation Index (CAI): 0.778. Curator(s): M. Chaplin; Protein involved in S-adenosylmethionine-dependent methyltransferase activity, transferase activity and precorrin-2 C20-methyltransferase activity.
 
 
 0.988
HemD
Uroporphyrinogen-III synthase, putative; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.
 
 
 0.973
hemA
Glutamyl-tRNA reductase, putative; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
 
  
 0.956
hemL
Glutamate-1-semialdehyde 2,1-aminotransferase, putative; GC: 51.27%; Codon Adaptation Index (CAI): 0.772. Curator(s): M. Chaplin, T. Kitten; Protein involved in glutamate-1-semialdehyde 2,1-aminomutase activity.
 
  
 0.911
SSA_0472
Precorrin-3B C17-methyltransferase, putative; GC: 44.9%; Codon Adaptation Index (CAI): 0.78. Curator(s): M. Chaplin; Protein involved in precorrin-3B C17-methyltransferase activity.
  
  
 0.894
SSA_0473
Precorrin-6x reductase, putative; GC: 51.6%; Codon Adaptation Index (CAI): 0.768. Curator(s): M. Chaplin; Protein involved in precorrin-6A reductase activity.
     
 0.891
SSA_0475
CbiK protein, putative; GC: 48.44%; Codon Adaptation Index (CAI): 0.797. Curator(s): M. Chaplin; Protein involved in sirohydrochlorin cobaltochelatase activity.
 
   
 0.874
Your Current Organism:
Streptococcus sanguinis SK36
NCBI taxonomy Id: 388919
Other names: S. sanguinis SK36, Streptococcus sanguinis str. SK36, Streptococcus sanguinis strain SK36
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